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POLR1B Antibody

  • 货号：
    CSB-PA070002
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9H9Y6
  • 基因名：
    POLR1B
  • 别名：
    A127 antibody; DNA directed RNA polymerase I 135kDa polypeptide antibody; DNA directed RNA polymerase I antibody; DNA directed RNA polymerase I subunit RPA2 antibody; DNA-directed RNA polymerase I 135 kDa polypeptide antibody; DNA-directed RNA polymerase I subunit rpa2 antibody; FLJ10816 antibody; FLJ21921 antibody; MGC131780 antibody; OTTHUMP00000161989 antibody; OTTHUMP00000203643 antibody; OTTHUMP00000203645 antibody; POLR 1B antibody; polr1b antibody; Polymerase (RNA) I polypeptide B 128kDa antibody; Polymerase (RNA) I polypeptide B antibody; RNA polymerase I polypeptide B antibody; RNA polymerase I subunit 2 antibody; RPA 135 antibody; RPA116 antibody; RPA135 antibody; RPA2 antibody; RPA2_HUMAN antibody; Rpo1 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RPA135.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
  • 基因功能参考文献：
    1. PTEN represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 complex PMID: 16055704
    2. CK2 has the potential to regulate Pol I transcription at multiple levels, in preinitiation complex (PIC) formation, activation, and reinitiation of transcription. PMID: 16880508
    3. Human Maf1 protein negatively regulates transcription by all three nuclear Pols. Changes in Maf1 expression affect Pol I-dependent transcription in human glioblastoma lines. PMID: 17499043
    4. The average FIX expression level of the rDNA recombinants was additionally enhanced to that from a strong Pol II promoter as a result of elimination of position effects. PMID: 18194663
  • 亚细胞定位：
    Nucleus, nucleolus. Chromosome.
  • 蛋白家族：
    RNA polymerase beta chain family
  • 数据库链接：

    HGNC: 20454

    OMIM: 602000

    KEGG: hsa:84172

    STRING: 9606.ENSP00000263331

    UniGene: Hs.745127