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RAP2C Antibody

  • 货号：
    CSB-PA003939
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MCF7 cells using Rap 2C Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y3L5
  • 基因名：
    RAP2C
  • 别名：
    2010200P20Rik antibody; AI194294 antibody; AL022976 antibody; BOS_25229 antibody; DKFZp313B211 antibody; MGC143331 antibody; OTTHUMP00000024037 antibody; OTTMUSP00000019067 antibody; RAP2C antibody; RAP2C; member of RAS oncogene family antibody; RAP2C_HUMAN antibody; Ras related protein Rap 2c antibody; Ras-related protein Rap-2c antibody; RP23-15D12.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Rap 2C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
  • 基因功能参考文献：
    1. Study found that SCII upregulated the expression of miR-204 and downregulated the expression of RAP2C; that hypoxia increased the expression of miR-204 and decreased the expression of RAP2C, and overexpression of RAP2C attenuates the effect of hypoxia on apoptosis rate; and miR-204 could directly bind to RAP2C, and could regulate the expression of RAP2C. PMID: 28714326
    2. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID: 23885123
    3. This work demonstrates that Rap2C is a new member of the Rap2 subfamily of proteins, able to bind guanine nucleotides with peculiar properties, and differently expressed by various hematopoietic subsets PMID: 16213650
    4. RAP2C is a novel member of the Ras family, belonging to the Rap branch of small GTPase proteins and may be involved in SRE-mediated gene transcription. PMID: 17447155
  • 亚细胞定位：
    Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.
  • 数据库链接：

    HGNC: 21165

    KEGG: hsa:57826

    STRING: 9606.ENSP00000340274

    UniGene: Hs.119889