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  4. Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA)

Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA)

In Stock
  • 中文名称：
    牛PRKRA重组蛋白
  • 货号：
    CSB-EP644142BO
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP644142BO could indicate that this peptide derived from E.coli-expressed Bos taurus (Bovine) PRKRA.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP644142BO could indicate that this peptide derived from E.coli-expressed Bos taurus (Bovine) PRKRA.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    PRKRA
  • Uniprot No.：
  • 别名：
    PRKRA; Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Protein activator of the interferon-induced protein kinase; Protein kinase; interferon-inducible double-stranded RNA-dependent activator
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    39.4 kDa
  • 表达区域：
    1-313aa
  • 氨基酸序列
    MSQSRHRAAAPPMEREDSGTFSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNMVGHSLGCTWHSLRNSPGEKINLLKRSLLSIPNTDYIQLLSEIAKEQGFNITYLDIEELSANGQYQCLAELSTSPITVCHGSGISCSSAQSDAAHNALQYLKIIAERK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner.
  • 基因功能参考文献：
    1. Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT, PRKRA) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes. PMID: 12440939
  • 亚细胞定位：
    Cytoplasm, perinuclear region. Cytoplasm.
  • 蛋白家族：
    PRKRA family
  • 数据库链接：

    KEGG: bta:282875

    STRING: 9913.ENSBTAP00000001451

    UniGene: Bt.13570