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  4. Recombinant Chicken Transcription factor SOX-10 (SOX10)

Recombinant Chicken Transcription factor SOX-10 (SOX10)

  • 中文名称：
    鸡SOX10重组蛋白
  • 货号：
    CSB-YP896207CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡SOX10重组蛋白
  • 货号：
    CSB-EP896207CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡SOX10重组蛋白
  • 货号：
    CSB-EP896207CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡SOX10重组蛋白
  • 货号：
    CSB-BP896207CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡SOX10重组蛋白
  • 货号：
    CSB-MP896207CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SOX10
  • Uniprot No.：
  • 别名：
    SOX10; Transcription factor SOX-10; cSOX10
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-461
  • 氨基酸序列
    MADDQDLSEV EMSPVGSEDH HCLSPGPSMA SDNSSHLASS GNGEMGKVKK EQQDSEADDD KFPVCIREAV SQVLSGYDWT LVPMPVRVNG SNKSKPHVKR PMNAFMVWAQ AARRKLADQY PHLHNAELSK TLGKLWRLLN ESDKRPFIEE AERLRMQHKK DHPDYKYQPR RRKNGKATQG EGEGQVEGEA GGAASIQAHY KNAHLDHRHP GEGSPMSDGH PEHSSGQSHG PPTPPTTPKT ELQAGKADSK REGRSLGEGG KPHIDFGNVD IGEISHEVMS NMETFDVNEF DQYLPPNGHA GHPGHVGGYA AAAGYGLGSA LAAASGHSAW ISKQHGVSLS ATTSPVVDSK AQVKTEGSAP GGHYTDQPST SQIAYTSLSL PHYGSAFPSI SRPQFDYPDH QPSGPYYSHS SQASGLYSAF SYMGPSQRPL YTAISDPAPS VPQSHSPTHW EQPVYTTLSR P
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.
  • 基因功能参考文献：
    1. results reveal important tissue-specific inputs into Sox10 expression in the developing embryo PMID: 28012818
    2. Data suggest that an 8.3-kb deletion upstream of the SOX10 transcription start site is the causal mutation underlying the Dark brown mutational phenotype in chickens. PMID: 21210960
    3. high levels of Sox10, Sox9, or Sox8 expression in the neural tube are capable of inducing a migratory neural crest-like phenotype PMID: 15768395
    4. Expression of SOX10, a transcription factor involved in oligodendrocyte development and maintenance, is lower in acid sphingomyelinase-deficient mice than in wild-type. PMID: 19187445
    5. study demonstrates that Sox10 is expressed in Bergmann glial cells and that its DNA binding activity, mRNA, and protein levels as well as its transcriptional behavior augments upon the activation of metabotropic Glu receptors PMID: 19425178

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 数据库链接：

    KEGG: gga:395573

    STRING: 9031.ENSGALP00000020056

    UniGene: Gga.4428