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  4. Recombinant Mouse Krueppel-like factor 7 (Klf7)

Recombinant Mouse Krueppel-like factor 7 (Klf7)

  • 中文名称：
    小鼠Klf7重组蛋白
  • 货号：
    CSB-YP860365MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klf7重组蛋白
  • 货号：
    CSB-EP860365MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Klf7重组蛋白
  • 货号：
    CSB-EP860365MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klf7重组蛋白
  • 货号：
    CSB-BP860365MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klf7重组蛋白
  • 货号：
    CSB-MP860365MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Klf7
  • Uniprot No.：
  • 别名：
    Klf7Krueppel-like factor 7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-301
  • 氨基酸序列
    MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI SETFGEDLDC FLHASPPPCI EESFRRLDPL LLPVEATICE KSSAVDILLS RDKLLSETCL SLQPTSSSLD SYTAVNQAQL NAVTSLTPPS SPELSRHLVK TSQTLSAVDG TVTLKLVAKK ASLSSVKVGG VAAAAAVTPA GAVKSGQSDS EQGGGGADTC PENKKRVHRC QFNGCRKVYT KSSHLKAHQR THTGEKPYKC SWEGCEWRFA RSDELTRHYR KHTGAKPFKC NHCDRCFSRS DHLALHMKRH I
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional factor. Plays a critical role in neuronal morphogenesis. Represses the corneal epithelium differentiation. Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin.
  • 基因功能参考文献：
    1. Our findings suggest that KLF7 promotes DPSN axonal plasticity and the formation of synapses with motor neurons at the caudal spinal cord, leading to improved functional recovery PMID: 28884027
    2. was upregulated in quiescent satellite cell and nonproliferating myoblasts. PMID: 26930448
    3. Data show that adult corticospinal tract (CST) neurons failed to up-regulate KLF7 in response to axon injury, and overexpression of VP16-KLF7 in vivo promoted both sprouting and regenerative axon growth in the CST of adult mice. PMID: 22529377
    4. lack of a KLF family member affects dopaminergic neuron development. PMID: 21093432
    5. KLF7 inactivation in Klf7-null mice decreases the expression of the neurogenic marker brain lipid-binding protein/fatty acid-binding protein 7 (BLBP/FABP7) in neural stem cells (NSCs). PMID: 20580711
    6. Klf7 gene ablation reduces TrkA expression in sensory neurons due to effect on cell death PMID: 15937222
    7. Klf7 is important for neuronal morphogenesis in selected regions of the central nervous system. PMID: 15964824
    8. mice without Kruppel-like factor 7 activity die at birth and display hypoplastic olfactory bulbs which lack peripheral innervation PMID: 16814267
    9. Cooperation between Brn3a and Klf7 is required for endogenous TrkA gene expression and the survival of nociceptive sensory neurons. PMID: 17011544
    10. Results advance knowledge of transcriptional regulation of olfactory neurogenesis and KLF7 action. PMID: 17123745
    11. Upregulation of adiponectin protein by (-)-catechin may involve, at least in part, suppression of KLF7 in 3T3-L1 cells. PMID: 17164435

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Widely expressed. Detected in the cornea epithelium (at protein level).
  • 数据库链接：

    KEGG: mmu:93691

    STRING: 10090.ENSMUSP00000054674

    UniGene: Mm.29466