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  4. Recombinant Mouse Protein odd-skipped-related 1 (Osr1)

Recombinant Mouse Protein odd-skipped-related 1 (Osr1)

  • 货号：
    CSB-YP895767MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP895767MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP895767MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP895767MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP895767MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Osr1
  • Uniprot No.：
  • 别名：
    Osr1; Odd1; Protein odd-skipped-related 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-266
  • 氨基酸序列
    MGSKTLPAPV PIHPSLQLTN YSFLQAVNGL PTVPSDHLPN LYGFSALHAV HLHQWTLGYP AMHLPRSSFS KVPGAVSSLM DARFQLPAFP WFPHVIHPKP EITAGGSGAA LKTKPRFDFA NLALAATQED PTKLGRGEGP GSPAGGLGAL LDVTKLSPEK KPTRGRLPSK TKKEFVCKFC GRHFTKSYNL LIHERTHTDE RPYTCDICHK AFRRQDHLRD HRYIHSKEKP FKCQECGKGF CQSRTLAVHK TLHSQVKELK TSKIKC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.
  • 基因功能参考文献：
    1. Osr1 plays a coordinating role in appropriate skull closure and cranial bone formation by negative regulation. PMID: 29234951
    2. Transcriptome and functional analyses reveal that Osr1(+) cells provide a critical pro-myogenic niche via the production of muscle connective tissue specific extracellular matrix components and secreted signaling factors. PMID: 29084951
    3. Hypothalamic OSR1 expression is suppressed by enhanced postnatal (maternal) care, but elevated by inflammatory microglia. PMID: 28852125
    4. In contrast to H2A-interacting proteins, the H2A.Z-interacting proteins are involved in transcriptional regulation. We found that the transcription factor Osr1 interacts with H2A.Z both in vitro and in vivo. It also mediates H2A.Z incorporation to a large number of target sites and regulates gene expression PMID: 28862252
    5. These results indicate that OSR1 and SPAK cooperatively regulate NKCC1-dependent spermatogenesis in a SC-restricted manner. PMID: 27853306
    6. Osr1 is a candidate gene implicated in the pathogenesis of vesicoureteric reflux and congenital abnormalities of the kidney and urinary tract in mice PMID: 28724605
    7. Our data reveal that together SPAK and OSR1 play essential roles in the pathway along the distal convoluted tubules that responds to fluctuations in plasma potassium PMID: 27068441
    8. odd-skipped related 1 is involved in regulation of mammalian kidney development PMID: 25834070
    9. ROMK1 protein abundance and activity are down-regulated by SPAK and OSR1 PMID: 25322850
    10. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells PMID: 25362046
    11. WNK 1, 3, 4, OSR1, and SPAK signaling system known to play a role in regulating the phosphorylation status, and hence activity of the CCCs in other tissues, is also present in the rat and human lenses. PMID: 25515571
    12. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. PMID: 24167250
    13. OSR1 is expressed in proximal renal tubules and participates in the regulation of FGF23 release and renal tubular phosphate transport. PMID: 23095210
    14. WNK1 activation of the OSR1 signaling cascade is an essential pathway that regulates angiogenesis and cardiac formation during mouse embryo development. PMID: 23386621
    15. OSR1 is expressed in human mesenchymal stem cells, the blastemal component of Wilms tumors and CD24+/CD133+ progenitor cells isolated from the mature kidney. PMID: 21821672
    16. Studies indicate that the Osr1 conditional mice will be valuable for tissue-specific analysis of the roles of Osr1 in embryonic and postnatal developmental processes. PMID: 21462293
    17. These data indicate that Osr1 and Osr2 function redundantly to control synovial joint formation. PMID: 21262216
    18. Odd 1 is essential for heart and intermediate mesoderm development PMID: 16223478
    19. Odd1 plays an important role in establishing kidney precursor cells, and in regulating their differentiation into kidney tubular tissue. PMID: 16790474
    20. Osr1 function is limited to establishing the nephron progenitor pool. PMID: 18835385
    21. the distinct functions of Osr1 and Osr2 during mouse development result from evolutionary divergence of their cis regulatory sequences rather than distinct biochemical activities of their protein products. PMID: 19389375

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Odd C2H2-type zinc-finger protein family
  • 数据库链接：

    KEGG: mmu:23967

    STRING: 10090.ENSMUSP00000055486

    UniGene: Mm.45055