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  4. Recombinant Mouse RNA-binding protein 20 (Rbm20), partial, partial

Recombinant Mouse RNA-binding protein 20 (Rbm20), partial, partial

  • 中文名称：
    小鼠Rbm20重组蛋白
  • 货号：
    CSB-YP659743MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rbm20重组蛋白
  • 货号：
    CSB-EP659743MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rbm20重组蛋白
  • 货号：
    CSB-EP659743MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rbm20重组蛋白
  • 货号：
    CSB-BP659743MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rbm20重组蛋白
  • 货号：
    CSB-MP659743MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbm20
  • Uniprot No.：
  • 别名：
    Rbm20; RNA-binding protein 20; RNA-binding motif protein 20
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

问答及客户评论

■ 常见问题解答
Q:

Is this protein functionally-folded? And after transfection through nucleovector does it function like a native protein?

A:
Thanks for your inquiry. This protein has a lot of phosphorylation modifications, the expression of the insect system can effectively fold a wide range of post-translational modifications, and we are purified under mild conditions, theoretically it can be folded correctly, but we did not detect it, so we can not guarantee.

靶点详情

  • 功能：
    RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin).
  • 基因功能参考文献：
    1. Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy. PMID: 27889803
    2. Inhibition of the RNA binding motif-20-based titin splicing system upregulates compliant titins, which improves diastolic function and exercise tolerance in the transverse aortic constriction/deoxycorticosterone acetate model PMID: 27630136
    3. Study demonstrates that Rbm20 is expressed in early cardiogenesis and functions in the patterning of cardiac gene expression. PMID: 24584570
    4. Nuclear retention domains have been identified in RBM20 which is a nuclear protein regulating alternative splicing of expressed genes. PMID: 23886709
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Predominantly expressed in striated muscle, with highest expression in the heart. In differentiating myoblasts, expression correlates with sarcomere assembly: expression peaks when alpha-actinin is localized mainly in mature Z bodies within the nascent my
  • 数据库链接：

    KEGG: mmu:73713

    STRING: 10090.ENSMUSP00000129447

    UniGene: Mm.313695