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  4. Recombinant Mouse Src-like-adapter (Sla)

Recombinant Mouse Src-like-adapter (Sla)

  • 货号：
    CSB-YP736755MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP736755MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP736755MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP736755MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP736755MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sla
  • Uniprot No.：
  • 别名：
    Sla; Slap; Slap1; Src-like-adapter; Src-like-adapter protein 1; SLAP-1; mSLAP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-281
  • 氨基酸序列
    GNSMKSTSP PSERPLSSSE GLESDFLAVL TDYPSPDISP PIFRRGEKLR VISDEGGWWK AISLSTGRES YIPGICVARV YHGWLFEGLG RDKAEELLQL PDTKIGSFMI RESETKKGFY SLSVRHRQVK HYRIFRLPNN WYYISPRLTF QCLEDLVTHY SEVADGLCCV LTTPCLAQNI PAPTSHPSPC TSPGSPVTLR QKTFDWKRVS RLQEGSEGAE NPLRVDESLF SYGLRESIAS YLSLTGDDSS SFDRKKKSLS LMYTGSKRKS SFFSAPQYFE D
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
  • 基因功能参考文献：
    1. SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke PMID: 25301707
    2. SLAP is a critical regulator of B-cell development and function and its deficiency leads to decreased autoreactive B cells that are otherwise maintained by inefficient receptor editing or failed negative selection. PMID: 24440645
    3. Src-like adaptor protein (SLAP) functions as a negative regulator of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) generation of monocyte-derived dendritic cells of bone marrow origin. PMID: 21220694
    4. SLAP deficiency dramatically reduces both the incidence and severity of arthritis and prevents development of chronic arthritis in the double SKG (mutant ZAP70) Src-like adapter protein (SLAP) knockout mouse model. PMID: 21248251
    5. SLAP negatively regulates differentiation of osteoclasts and proliferation of their precursors. PMID: 20225239
    6. SLAP functions in a pathway that requires the phosphorylated TCRzeta chain and the Src family kinase Lck, but not ZAP-70 (zeta-associated protein of 70 kD). PMID: 16027224
    7. SLAP has a conserved function in B and T cells by adapting c-Cbl to the antigen-receptor complex and targeting it for degradation PMID: 17110436

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  • 亚细胞定位：
    Cytoplasm. Endosome. Note=Colocalizes with endosomes.
  • 组织特异性：
    Predominantly expressed in lymphoid tissues. Highly expressed in spleen, thymus and lymph nodes. Weakly expressed in lung and brain. Expressed in T-cells and at low level in B-cells.
  • 数据库链接：

    KEGG: mmu:20491

    STRING: 10090.ENSMUSP00000131865

    UniGene: Mm.7601