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  4. Recombinant Mouse TNFAIP3-interacting protein 2 (Tnip2)

Recombinant Mouse TNFAIP3-interacting protein 2 (Tnip2)

  • 中文名称：
    小鼠Tnip2重组蛋白
  • 货号：
    CSB-YP860367MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tnip2重组蛋白
  • 货号：
    CSB-EP860367MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tnip2重组蛋白
  • 货号：
    CSB-EP860367MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tnip2重组蛋白
  • 货号：
    CSB-BP860367MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tnip2重组蛋白
  • 货号：
    CSB-MP860367MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tnip2
  • Uniprot No.：
  • 别名：
    Tnip2; Abin2; TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2; ABIN-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-430
  • 氨基酸序列
    MSSGDPRSGR QDGAPRAAAA LCGLYHEAGQ QLQRLKDQLA ARDALIASLR TRLAALEGHT APSLVDALLD QVERFREQLR RQEEGASETQ LRQEVERLTE RLEEKEREMQ QLMSQPQHEQ EKEVVLLRRS VAEKEKARAA SDVLCRSLAD ETHQLRRTLA ATAHMCQHLA KCLDERQCAQ GDAGEKSPAE LEQTSSDASG QSVIKKLQEE NRLLKQKVTH VEDLNAKWQR YDASRDEYVK GLHAQLKRRQ VPLEPELMKK EISRLNRQLE EKISDCAEAN QELTAMRMSR DTALERVQML EQQILAYKDD FKSERADRER AHSRIQELEE KIMSLMYQVS QRQDSREPGP CRIHTGNKTA KYLEMDALEH VTPGGWRPES RSQQMEPSAE GGHVCTAQRG QGDLQCPHCL RCFSDEQGEA FLRHLSECCQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
  • 基因功能参考文献：
    1. s found that TNIP2 was correlated with the activation of NF-kappaB in cerulein-stimulated AR42J cells, and TNIP2 over-expression inhibited the inflammatory response caused by cerulein. Moreover, results suggest that TNIP2 over-expression relieved the cerulein-triggered inflammatory response and AP-induced myocardial injury in mice. PMID: 29176547
    2. ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha. PMID: 21784860
    3. optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105 PMID: 15169888
    4. ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration PMID: 16480954
    5. ABIN-2 acts to positively regulate the Erk signaling potential by stabilizing TPL-2. PMID: 16633345

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Ubiquitously expressed in all tissues examined.
  • 数据库链接：

    KEGG: mmu:231130

    STRING: 10090.ENSMUSP00000085030

    UniGene: Mm.28615