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  4. Recombinant Rat E3 ubiquitin-protein ligase TRIM17 (Trim17)

Recombinant Rat E3 ubiquitin-protein ligase TRIM17 (Trim17)

  • 中文名称：
    大鼠Trim17重组蛋白
  • 货号：
    CSB-YP894835RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Trim17重组蛋白
  • 货号：
    CSB-EP894835RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Trim17重组蛋白
  • 货号：
    CSB-EP894835RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Trim17重组蛋白
  • 货号：
    CSB-BP894835RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Trim17重组蛋白
  • 货号：
    CSB-MP894835RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim17
  • Uniprot No.：
  • 别名：
    Trim17; Terf; E3 ubiquitin-protein ligase TRIM17; EC 2.3.2.27; RING-type E3 ubiquitin transferase TRIM17; Testis RING finger protein; Tripartite motif-containing protein 17
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-477
  • 氨基酸序列
    MDAVELARRL QEEATCSICL DYFTDPVMTA CGHNFCRECI QMSWEKGKGK KGKKKQKGSF PCPECREMSP QRNLRPNRLL TKVAEMARQH PGLHKRDLCQ IHQEPLKLFC QDDQTPICVV CREAQEHRMH RVLPLDEAAR EYKLRLEEDI KYLREEMMKT ETLQAKEEQT LTEWQERVKE RRERILEEFQ KVVLFLVEEE RRLLQILKKE EDDTLGKLQD SKASLDHQSR SLDLILLQLE EQTQQEPLQM LQDVKDTLTR KESLSMQYPE VVLPVAIKTV CRVPGQIEVL KSFQEDVVPD PSTAYPYLLL YESRQRRYLS PPPEGSAPYS KDRFLAYPCA VGQKSFSSGR HYWEVGMNLT GDALWALGVC RDNVSRKDRV LKSPENGFWV VQLSKGKKHL PLLPNSIPVT LTEPPSHMGI FLDFQAGEVS FYSVNDGSHL HSFSQVAFPG PLLPFFCLGS PKSGQMVIST VTMWVKG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation. Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1. Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells. Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1.
  • 亚细胞定位：
    Cytoplasm. Lysosome.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Expressed almost exclusively in the testis.
  • 数据库链接：

    KEGG: rno:64702

    STRING: 10116.ENSRNOP00000003885

    UniGene: Rn.48706