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  4. Recombinant Mouse Somatostatin receptor type 4 (Sstr4)

Recombinant Mouse Somatostatin receptor type 4 (Sstr4)

  • 中文名称：
    小鼠Sstr4重组蛋白
  • 货号：
    CSB-CF022727MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Sstr4
  • Uniprot No.：
  • 别名：
    Sstr4; Smstr4; Somatostatin receptor type 4; SS-4-R; SS4-R; SS4R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-384
  • 氨基酸序列
    MNAPATLLRGVEDTTWTPGINASWAPEQEEDAMGSDGTGTAGMVTIQCIYALVCLVGLVG NALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVRSAAALRHWPFGAVLCRAVLS VDGLNMFTSVFCLTVLSVDRYVAVVHPLRTATYRRPSVAKLINLGVWLASLLVTLPIAVF ADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLPPVLAIGLCYLLIVGKMRAVALR GGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANS CANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGAGCICPPL PCQQEPVQAEPGCKQVPFTKTTTF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.
  • 基因功能参考文献：
    1. Study provides first evidence that somatostatin 4 receptor activation is involved in the behavioral and neuroendocrine alterations induced by chronic stress with a crucial role of plastic changes in the amygdala. PMID: 28161436
    2. The results of this study revealed that sst4 mediates anxiolytic and antidepressant-like effects by enhancing the stress-responsiveness of several brain regions with special emphasis on the amygdala. PMID: 26387439
    3. SSTR4 and delta-Opioid receptor (dOR) exist in a heteromeric complex and function in synergistic manner. PMID: 24416361
    4. SSTR4-like immunoreactivity increases in ApoD(-/) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle. PMID: 22581439
    5. SSTR4 ablation has an effect on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine PMID: 19426160
    6. The effect of sst2 receptor knockout on sst4 receptor mRNA localization and binding sites throughout the brain has been determined. PMID: 11897118
    7. Somatostatin sst(4) receptor-selective agonists could be potential candidates for the development of a completely novel group of anti-inflammatory drugs for the treatment of airway inflammation and hyperresponsiveness. PMID: 17961545
    8. Somatostatin receptor subtype 4 couples to the M-current to regulate seizures. PMID: 18385315
    9. during the inflammatory conditions the released somatostatin has pronounced counterregulatory effects through sst(4) receptor activation. PMID: 19622729
    10. the expression, localization, and inflammation-induced alterations of sst(4) receptors in murine and human lungs PMID: 19687471

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:20608

    STRING: 10090.ENSMUSP00000044573

    UniGene: Mm.35324