Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Rat Ectonucleoside triphosphate diphosphohydrolase 2 (Entpd2)

Recombinant Rat Ectonucleoside triphosphate diphosphohydrolase 2 (Entpd2)

  • 中文名称：
    大鼠Entpd2重组蛋白
  • 货号：
    CSB-CF007691RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Entpd2
  • Uniprot No.：
  • 别名：
    Entpd2; Cd39l1; Ectonucleoside triphosphate diphosphohydrolase 2; NTPDase 2; CD39 antigen-like 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-495
  • 氨基酸序列
    MAGKLVSLVPPLLLAAAGLTGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKENDTGIVGQHSSCDVQGGGISSYANDPSKAGQSLVRCLEQALRDVPRDRHASTPLYLGATAGMRPFNLTSPEATARVLEAVTQTLTQYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRPRKGTLGAMDLGGASTQITFETTSPSEDPGNEVHLRLYGQHYRVYTHSFLCYGRDQILLRLLASALQIHRFHPCWPKGYSTQVLLQEVYQSPCTMGQRPRAFNGSAIVSLSGTSNATLCRDLVSRLFNISSCPFSQCSFNGVFQPPVAGNFIAFSAFYYTVDFLTTVMGLPVGTLKQLEEATEITCNQTWTELQARVPGQKTRLADYCAVAMFIHQLLSRGYHFDERSFREVVFQKKAADTAVGWALGYMLNLTNLIPADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQVRSAKSPGAL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.
  • 基因功能参考文献：
    1. Apo and complex structures of the rat NTPDase2 extracellular domain and Legionella pneumophila NTPDase1. PMID: 23830739
    2. two ENTPD isoforms, ENTPD-1 and -2, are expressed in adult rat ventricular CFs PMID: 23677997
    3. NTPDase2 overexpression modulates pro-inflammatory cytokine production and platelet reactivity. PMID: 22038661
    4. ATP acts in an autocrine manner to promote its own release and that of dopamine, an action that is controlled by the level of E-NTPDase1/CD39 expression PMID: 21325440
    5. NTPDase2 was expressed in the periportal region surrounding intrahepatic bile ducts PMID: 12395323
    6. novel inducible release of full length particulate CD39, and propose its role in the physiological context of pancreatic secretion. PMID: 12832497
    7. NTPDase2 is associated with nonmyelinating Schwann cells of the rat sciatic nerve. It was associated with the satellite glial cells in dorsal root ganglia and sympathetic ganglia, and with the enteric ganglion glia. PMID: 14730706
    8. hepatic stellate cells differentially regulate nucleoside triphosphate diphosphohydrolase expression after activation PMID: 14764443
    9. the amplitude of the long-lasting phase of the Ca(2+) signal depended on the balance between agonist degradation by ectonucleotidases and agonist transport, by diffusion and convection, from bulk solution to the EC surface PMID: 15004436
    10. alternative coding of the intracellular C-terminal domain contributes distinctive phenotypic variation with respect to extracellular nucleotide specificity, hydrolysis kinetics, protein kinase-dependent intracellular regulation and protein trafficking PMID: 15362980
    11. down-regulation in biliary cirrhosis PMID: 15651265
    12. NTPDase2 has a role in portal fibroblast regulation of bile duct epithelium proliferation PMID: 15799977
    13. NTPDase2 may modulate inflammatory reactions within the central nervous system and could represent a useful therapeutic target in human disease. PMID: 16414200
    14. NTPdase2 expression profile was studied in the Walker 256 carcinoma. PMID: 17574764
    15. NTPDase2 ectodomain refolded from bacterial inclusion bodies was characterized. PMID: 17910474
    16. Data showed that Entpd2 as the enzyme with the highest expression in left ventricle. PMID: 18201730
    17. IL-6 transcriptionally downregulates NTPDase2 expression by portal fibroblasts via actions at specific promoter elements independently of myofibroblastic differentiation PMID: 18202114
    18. The structure of the extracellular domain of Rattus norvegicus NTPDase2 in an active state at resolutions between 1.7 A and 2.1 A in four different forms, is presented. PMID: 18458329
    19. Selective NTPDase2 expression modulates in vivo rat glioma growth. PMID: 19558578

    显示更多

    收起更多

  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    GDA1/CD39 NTPase family
  • 组织特异性：
    Expressed in brain, heart, vas deferens, kidney, skeletal muscle, thymus, lung and spleen. Weak expression in liver.
  • 数据库链接：

    KEGG: rno:64467

    STRING: 10116.ENSRNOP00000017829

    UniGene: Rn.8276