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  4. Recombinant Mouse C-C motif chemokine 5 protein (Ccl5)

Recombinant Mouse C-C motif chemokine 5 protein (Ccl5)

In Stock
  • 货号：
    CSB-AP001241MO
  • 规格：
    ￥852
  • 图片：
  • 其他：

产品详情

  • 纯度：
    >97% as determined by SDS-PAGE.
  • 内毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T lymphocytes is in a concentration range of 1.0-10 ng/ml.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ccl5; Scya5C-C motif chemokine 5; MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.Coli
  • 分子量：
    7.9 kDa
  • 表达区域：
    24-91aa
  • 氨基酸序列
    SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    0.2 μm filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA,Lyophilized
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
  • 基因功能参考文献：
    1. the results show that Broadleaf Mahonia is a novel effective antiinflammatory herb in vitro and ex vivo, and that CCL5 may be closely associated with Granulomatous lobular mastitispathogenesis PMID: 29138800
    2. miR-155 enhances venous neointima formation through the autocrine and paracrine effects of smooth muscle-like cell-derived RANTES in a nuclear factor kappaB-dependent manner in arteriovenous shunts. PMID: 29477204
    3. Taken together, our data suggest that CCR5 regulates insulin signaling in hypothalamus which contributes to systemic insulin sensitivity and glucose metabolism. PMID: 27898058
    4. identifies the essential role of the chemoattractive cytokine CCL5 for liver disease progression and especially hepatocellular carcinoma development PMID: 28011329
    5. Breast cancer cell CCL5 mediates bone marrow independent angiogenesis via paracrine signaling. PMID: 27863423
    6. Studied the effects of CCL5-CCR5 interactions in breast cancer metabolism, and findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis. PMID: 29216863
    7. RANTES levels were associated with TMS measures of cortical synaptic excitability, but not with long-term potentiation (LTP)-like plasticity. PMID: 26733422
    8. study found that the inflammatory chemokine CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN-expressed D6. PMID: 28674178
    9. A robust up-regulation of RANTES within the brain was seen in a mouse model of tick-borne encephalitis. PMID: 27576490
    10. This study showed that RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation. PMID: 26873938
    11. Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4(+) and CD8(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP-intoxicated mice. PMID: 27226559
    12. CCL5 deficiency resulted in reduced neointima formation after carotid artery injury and thrombosis. PMID: 27337700
    13. RANTES produced by renal tubular cells act as a key chemokine in acute kidney injury and HIF-1alpha regulated LncRNA-PRINS might be involved in RANTES production. PMID: 26725683
    14. Neutralization of circulating RANTES decreased liver neutrophilic infiltration PMID: 26799785
    15. CCL5 signaling through CCR5 may increase platelet counts during physiological stress. PMID: 26647394
    16. An intriguing finding was that S1P induced c-Fos-inhibited CCL5 directly and also indirectly through inhibition of the IFN-beta amplification loop PMID: 26246404
    17. platelet-derived CCL5 is an important link between platelet activation and neutrophil recruitment in acute colitis PMID: 26089223
    18. Nuclear FAK is associated with chromatin and exists in complex with transcription factors and their upstream regulators that control Ccl5 expression. Furthermore, FAK's immuno-modulatory nuclear activities may be specific to cancerous squamous epithelial cells, as normal keratinocytes do not have nuclear FAK. PMID: 26406376
    19. PRDX6 promotes lung tumor development via its mediated and CCL5-associated activation of the JAK2/STAT3 pathway. PMID: 25582888
    20. High levels of CCL5 expression in mouse and human cell lines might accelerate diffuse large Bcell lymphoma formation in diabetes mellitus. PMID: 24938715
    21. IL-17A contributes significantly to the pathogenesis of renal fibrosis by regulating RANTES-mediated inflammatory cell infiltration PMID: 25158055
    22. decreased CCL5 mRNA expression was observed in kidneys of lupus-prone mice with reduced Fli-1 expression. CCL5 protein expression was significantly decreased in endothelial cells transfected with Fli-1-specific small interfering RNA. PMID: 25098295
    23. We evaluated the mRNA expression of angiogenic and migration factors in MSC and found the expression of CCL5 mRNA was higher in AT-MSC than in BM-MSC or DT-MSC. PMID: 24171667
    24. These results show that IL-32gamma effectively promotes migration of activated T cells via CCL5 production in DCs. PMID: 24882804
    25. TLR4, rather than TLR2, regulates wound healing through TGF-beta and CCL5 expression PMID: 24252748
    26. HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-kappaB, AP-1, C/EBPalpha and C/EBPgamma transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways PMID: 24244375
    27. WT1 regulates the expression levels of Cxcl10 and Ccl5 in epicardial cells directly and indirectly through increasing the levels of IRF7. PMID: 23900076
    28. this study identifies a new role for SARM in CCL5 expression in macrophages. PMID: 24711619
    29. we found that IRF1 was essential for IL-1-induced expression of the chemokines CXCL10 and CCL5 PMID: 24464131
    30. CCL5 is a target gene for AhR, and might be associated with the pathology of dioxin exposure. PMID: 23810773
    31. These data provide in vivo evidence supporting the previously suggested role of Ccl5 in bone remodeling. PMID: 23553711
    32. Taken together the data presented strongly suggest that 4T1 mammary tumor cell invasion in vitro is promoted by D1 mesenchymal stem cell secretions, especially the chemokines CCL5 and CCL9. PMID: 23722213
    33. Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kappaB activation. PMID: 23935096
    34. Study uncovers a novel, chemokine-independent activity of the hematopoietically derived CCL5 that promotes mammary tumor progression via generating MDSCs in the bone marrow in cooperation with tumor-derived colony-stimulating factors. PMID: 23266888
    35. Alloreactive memory CD4(+) T cells contribute to increased expression and secretion of RANTES, and to the Tm and other inflammatory cells migration into the graft. PMID: 23498790
    36. Data indicate that enhanced tumorigenesis is dependent on microbiota-induced chemokine CCL5-driven inflammation, which in turn promotes epithelial activation of the IL-6 pathway, leading to cancer formation. PMID: 23696660
    37. Peptide inhibition of CXCL4-CCL5 interactions may represent a viable translational strategy to limit progression of abdominal aortic aneurysms. PMID: 23288157
    38. Attenuated behavioral hypersensitivity in CCL5-deficient mice observed in the current study could be a result of decreased macrophage infiltration, mobilization, and functional ability at injured sites in neuropathic pain. PMID: 22494919
    39. Chinese herbal antidotes A, H and C in combination can significantly inhibit the RANTES expression in serum and renal tissue of MRL/lpr mice. PMID: 21302497
    40. findings show that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta; impaired accumulation was in part attributable to the epigenetic silencing of key T cell-attracting inflammatory chemokine genes in decidual stromal cells PMID: 22679098
    41. Fbw7 gamma - mediated ubiquitination of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes. PMID: 22797700
    42. shikonin can effectively enhance anti-tumor potency of a gene-based cancer vaccine via the induction of RANTES expression at the skin immunization site. PMID: 22494696
    43. CCL5 functions within the glioblastoma microenvironment through CCR1 and CCR5 in a redundant manner. PMID: 22425022
    44. IL-15 can signal via IL-15Ralpha, JNK, and NF-kappaB to drive RANTES production by myeloid cells. PMID: 22447977
    45. These data confirm CCL5 is an essential factor for optimal pneumococcal adaptive immunity and show CD4(+) T cell responses to PspA(199-246) are largely resistant to CCL5 deficiency. PMID: 22178100
    46. the involvement of CCL5 in the pathogenesis of colorectal carcinoma PMID: 22205974
    47. Data identify the CCL5/CCR5 interaction as a possible novel molecular target for modulation of neovascularization and eventual tissue repair. PMID: 22214846
    48. Interferon alpha/beta control RANTES production during pneumococcal pneumonia in mice. PMID: 22156592
    49. RANTES/CCL5 mediates trafficking and homing of T lymphocytes, monocytes, and other leukocytes, and has been implicated in arterial injury and atherosclerosis. PMID: 21680945
    50. an important role for RANTES in sustaining CD8 T cell responses during a systemic chronic viral infection. PMID: 21814510

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    T-cell and macrophage specific.
  • 数据库链接：

    KEGG: mmu:20304

    STRING: 10090.ENSMUSP00000039600

    UniGene: Mm.284248