Human α-glutathione S-transferases,α-GST ELISA Kit

Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.

1. GSTA1 Expression Is Correlated With Aldosterone Level in KCNJ5-Mutated Adrenal Aldosterone-Producing Adenoma. PMID: 29165597
2. Data (including data from studies using single-molecule fluorescence imaging) suggest that, for GSTA1, there are at least two conformations of the protein, consistent with model that ligand binding promotes closure of carboxy-terminal helix over active site; study involved binding of glutathione analogs and enzyme inhibitors. PMID: 28677395
3. Combined GSTM1, GSTT1, GSTA1 and GSTP1 polymorphisms might be associated to the risk of clear cell renal cell carcinoma. PMID: 27500405
4. Data show that the glutathione S-transferase alpha 1(GSTA1) TT genotype was more frequent in hepatocellular carcinoma (HCC) than in non-HCC patients, suggesting that individuals carrying this genotype could be associated with 2-fold higher risk of developing HCCs. PMID: 27936036
5. Nrf-2 and Gst-a were more abundant in bone morrow of chronic myeloid leukemia(CML) patients compared with that of healthy donors. In addition, Nrf-2 and Gst-a were further up-regulated in samples of patients with weak response to IM. In conclusion, our study shows that rapid clearance of 4-HNE by Nrf-2/GST may represents a novel molecular basis of IM resistance in CML. PMID: 28267438
6. Study found an association, although not statistically significant between GSTA1 gene variants and perioperative serum alpha-GST level, an indicator for liver hepatotoxicity. PMID: 27179909
7. common polymorphisms in GSTA1, GSTM1 and GSTT1 are associated with susceptibility to bladder cancer in individuals from Balkan endemic nephropathy areas of Serbia. PMID: 27568660
8. Data show that a higher concentration of fluoride in the saliva was detected in children with a higher glutathione S-transferase (GST) activity. PMID: 27449362
9. polymorphisms not associated with bladder cancer susceptibility [meta-analysis] PMID: 27631264
10. Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients. PMID: 26691424
11. The frequency of GSTA1, GSTM1 and GSTP1 genotypes was not significantly different between progressive myoclonus epilepsy patients and controls PMID: 26552558
12. GSTA1 polymorphism is associated with different pregnancy-related conditions PMID: 26321410
13. this is the first population pharmacokinetic study to suggest that GSTA1 polymorphisms in adults are associated with busulfan pharmacokinetics PMID: 26419450
14. GST genotyping before hematopoietic stem cell transplantation may allow better prediction of busulfan pharmacokinetics and drug toxicity, and thereby improve outcome after busulfan and cyclophosphamide conditioning PMID: 25565670
15. the differences of PK in BU among different ethnic groups existed because of the different distribution frequencies of GST gene polymorphism in Chinese patients and Caucasian patients. PMID: 25730183
16. Data show that the distribution of the glutathione S-transferases alleles GSTA1*A/*B and GSTP1*A, *B, and *C in the Polish population correspond to the results of studies in Caucasians. PMID: 25867434
17. Patients with a GSTA1*A heterozygous variant had a lower exposure to 4-hydroxycyclophosphamide (4OHCTX) during cyclophosphamide treatment of lupus nephritis compared to wild-type patients. PMID: 26222310
18. Our data indicated that GSTA1 expression may be a target molecule in early diagnosis and treatment of lung cancer PMID: 25374180
19. Data suggest that cytochrome P450 3A4- and glutathione S-transferase A1-transfected -hepatoma cell line C3A may become a cell material in the biochemical artificial liver system. PMID: 24782212
20. The study found that GSTA1 polymorphism was associated with increased risk of Balkan endemic nephropathy. PMID: 25111321
21. Review/Meta-analysis: suggest that GSTA1 BB genotype was a risk factor for colorectal cancer, especially in Caucasian populations. PMID: 25778330
22. The distribution of genotype frequencies of the polymorphism GSTA1 was statistically different between cases and controls, and the presence of genotypes A / B and B / B suggests a protective role against the risk of PCa compared to genotype A / A. PMID: 25251951
23. The role of the glutathione S-transferase A1, M1, P1 and T1 gene polymorphisms and potential effect modification by occupational exposure to different chemicals in Serbian bladder cancer male patients, was investigated. PMID: 24914957
24. Increased GSTA1 levels are associated with delayed graft function. PMID: 24612768
25. The GSTA1*-69T and GSTO2*D142 variants are both associated with a significantly increased risk of asthma. PMID: 24471578
26. High expression of GSTA1 is associated with chronic obstructive pulmonary disease. PMID: 24344877
27. The polymorphism of GSTA1 (rs3957357) may not be associated with the risk of recurrent spontaneous abortion in Chinese Han population. PMID: 24390679
28. Combined GSTM1*0/GSTA1*A genotypes might be considered as genetic markers for cardiovascular death risk in ESRD patients, which may permit targeting of preventive and early intervention. PMID: 24423050
29. GSTA1 and CYP39A1 were found to be associated with busulfan clearance. When combined, the two haplotypes explained 17% of the variability in busulfan clearance. PMID: 24192117
30. Polymorphisms in GSTA1 gene is associated with secondary mixed phenotype acute leukemia. PMID: 24276031
31. Data indicate that genotypes of the GSTA1, GSTM1, GSTT1, and GSTP1 did not contribute independently towards the risk of bladder cancer, but in association with smoking, both GSTA1 and GSTM1 increase individual susceptibility to bladder cancer. PMID: 24075358
32. Data indicate that GSTA1 genotype may be predictive for doxorubicin efficacy but warrants further study. PMID: 24215845
33. GSTA1*A2 haplotype was associated with lower drug levels and higher drug clearance (P PMID: 23292236
34. Report increased GSTA1 in airways of asthmatics. PMID: 23647087
35. GSTA1 low or intermediate genoytpe was associated with a non-significant protective effect for esophageal adenocarcinoma and esophageal squamous cell carcinoma. PMID: 23731957
36. GST-a levels significantly correlated with exposure from mercury-containing dental amalgams in a dose-dependent fashion. PMID: 22893351
37. Ceramide may increase resistance to chemotherapeutics in Caco-2 cells by up-regulating the expression of GSTA1. PMID: 22993865
38. Data indicate that the GSTA1-1 catalytic promiscuity correlates strongly with characteristics of the thermodynamic partition function. PMID: 23649628
39. The interaction of the chemotherapeutic drug chlorambucil (CBL) with human GSTA1-1 (hGSTA1-1) using kinetic analysis, protein crystallography and molecular dynamics, is reprted. PMID: 23460799
40. GSTM1 and GSTA1 polymorphisms significantly impact the malignant potential of transitional cell carcinoma of the urinary bladder. PMID: 23394311
41. The GST genetic variants examined were not associated with susceptibility to coronary artery disease in our Taiwanese cohort. PMID: 23570881
42. GSTA1 levels may play a role in modulating enterocyte proliferation but do not influence differentiation or apoptosis. PMID: 23251616
43. Variability in GST genes (GSTA1, GSTT1, GSTP1, GSTA1) is not a major determinant of colorectal cancer susceptibility in the Central European population. PMID: 22697302
44. Results confirmed that patients with schizophrenia who were carriers of the GSTA1 *B risk allele had an increased MD in bilateral thalami and increased severity of auditory and global hallucinations in comparison with non-B carriers. PMID: 22959778
45. Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma. PMID: 22475179
46. The data suggest that menadione-induced JNK activation involves the production of reactive oxygen species, likely superoxide anion, and intracellular GSH levels play an important role in preventing GSTA1-JNK complex dissociation. PMID: 22906494
47. Tyr-9-induced localisation of a C-terminal helix (alpha9)of glutathione transferase A1-1 was ligand dependent, suggesting that the phenolic hydroxyl group of the active site tyrosine influences alpha9 dynamics by mediating the orientation of the bound ligand. PMID: 21530062
48. A significant association is found between the GSTA1 gene and an increased risk of recurrent miscarriage. PMID: 22633257
49. GSTA1 and the GSTO2 are asthma susceptible genes involved in increasing the risk of asthma development in the Italian population PMID: 22040239
50. After adjustment of confounding factors, GSTP1 Ile105Val, GSTA1 C-69T, and TGFbeta1 T869C polymorphisms were found to be significantly associated with the risk of Grade 2-3 radiation-induced fibrosis. PMID: 22079734

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Cytoplasm.

GST superfamily, Alpha family

Liver.

HGNC: 4626

OMIM: 138359

KEGG: hsa:2938

STRING: 9606.ENSP00000335620

UniGene: Hs.446309