Mouse cyclophilin A,CyPA ELISA Kit

Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates. Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans.

1. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation. PMID: 28981554
2. Endothelial cell-derived CypA (especially AcK-CypA) causes pulmonary artery hypertension by a presumptive mechanism involving increased EC apoptosis, inflammation, and oxidative stress. PMID: 28450293
3. ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of myosin light chains in vascular smooth muscle cells. PMID: 27825172
4. knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA both in vivo and in vitro. PMID: 27133068
5. CypA dually exerts pro-osteogenic and anti-osteoclastic effects. PMID: 26932182
6. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA. PMID: 25550208
7. CypA provided stability for NF-kappaB p65 and promoted NF-kappaB p65 nuclear translocation, resulting in increased nuclear accumulation and enhanced NF-kappaB activity. PMID: 25119989
8. Newborn CypA-deficient pups exhibited generalized, pronounced skeletal defects, while high-resolution micro-computed tomography analyses of the femurs and lumbar vertebrae revealed delayed or incomplete endochondral ossification. PMID: 25870110
9. Cyclophilin A secretion was increased in lymphocytes from atherogenic mice. PMID: 25115246
10. CD137-CD137L interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis. PMID: 24520398
11. Reactive oxygen species-dependent CypA secretion by endothelial cells is an important signaling mechanism through which endothelial cell reactive oxygen species regulate susceptibility of structural components of the aortic wall to aortic dissection. PMID: 24807872
12. CyPA is an important regulator for AngII-induced ROS generation in VSMC through interaction with p47phox and cell cytoskeleton, which enhances the translocation of p47phox to caveolae. PMID: 23846495
13. CYPA was identified as a novel host restriction factor that confered protection against rotavirus infection. PMID: 23303713
14. CyPA expression increases and may modulate inflammatory cell adhesion and interleukin-6 expression inducing vascular smooth muscle cell migration and inflammatory cell extravasation in a time-dependent manner PMID: 23201430
15. How does oxidative stress contribute to vascular disease? Data from vascular smooth muscle suggest that reduced glutathione peroxidase 1 (i.e., oxidative stress) promotes secretion of CypA which mediates paracrine inflammation of vasculature. PMID: 21782974
16. CsA inhibits BKV replication through CypA and NFAT, which may be potential targets of anti-BKV treatment PMID: 22642569
17. CyPA is an important Ca(2+) regulator in platelets, a critical mechanism for arterial thrombosis. PMID: 22740452
18. CypA is a key target for treating APOE4-mediated neurovascular injury and the resulting neuronal dysfunction and degeneration PMID: 22622580
19. truncated CyPA detected in brain following prion infection may have an important role in the activation of brain-derived primary astroglia and microglia in prion disease and perhaps other neurodegenerative or neuroinflammatory diseases. PMID: 22179611
20. Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion. PMID: 21441138
21. CyPA is required for Ang II-mediated cardiac hypertrophy by directly potentiating ROS production, stimulating the proliferation and migration of cardiac fibroblasts, and promoting cardiac myocyte hypertrophy in ApoE deficient mice. PMID: 21330604
22. data define a role for CyPA in atherosclerosis and suggest CyPA as a target for cardiovascular therapies PMID: 21173104
23. The CyPA/EMMPRIN activation pathway may play a relevant role in promoting the vulnerability of atherosclerotic plaques. PMID: 19758589
24. a novel function of CypA is required in the processing of RA-induced neuronal differentiation in p19 embryonal carcinoma cells PMID: 15047706
25. CyPA is a novel paracrine and autocrine modulator of EC functions in immune-mediated vascular disease PMID: 15111303
26. CyPA is highly expressed in in atherosclerotic plaques from the ApoE-/- mouse. It has proinflammatory effects on EC and may play an important role in the pathogenesis of inflammatory diseases. PMID: 15130913
27. CyP-A may perform a general function related to the binding of cargo for retrograde movement along microtubules PMID: 15496417
28. Among multiple potential intracellular ligands of T cells, CypA is the primary mediator of immunosuppression by cyclosporine. PMID: 15879096
29. CypA has an epigenetic function in protecting the paternal allele of Peg3 from DNA methylation and inactive histone modifications PMID: 17071620
30. These results show that MCMV replication depends upon cellular CyPA pathways in neural stem and progenitor cell (in a specific cell type-dependent fashion), that CyPA plays an important role in viral infection in this cell type. PMID: 17553872
31. lethal translocation of AIF to the nucleus requires interaction with CypA, suggesting a model in which two proteins that normally reside in separate cytoplasmic compartments acquire novel properties when moving together to the nucleus PMID: 17635954
32. CyPA plays a crucial role in vascular smooth muscle cell migration and proliferation, and inflammatory cell accumulation, thus regulating flow-mediated vascular remodeling and intima formation. PMID: 18541741
33. Apoe-/-Ppia-/- mice are completely protected from AngII-induced abdominal aortic aneurysm formation PMID: 19430489

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Cytoplasm. Secreted. Nucleus.

Cyclophilin-type PPIase family, PPIase A subfamily

Expressed in the kidney thick ascending limb (at protein level). Expressed in neurons and motor neurons (at protein level). Expressed in platelets.

KEGG: mmu:268373

STRING: 10090.ENSMUSP00000117987

UniGene: Mm.5246