Rat C-C chemokine receptor type 2(CCR2) ELISA kit

Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Mediates the recruitment of macrophages and monocytes to the injury site following brain injury.

1. CCR2 activation in nociceptive dorsal root ganglia neurons plays a role in the pathogenesis of gastric hyperalgesia associated with diabetic gastropathy. PMID: 29359616
2. Light exposure led to apoptosis of photoreceptors, which expressed CCL2, accelerating an inflammation-mediated cascade by activating and attracting microglia and monocytes and promoting their secretion of CCL2 in the injured position. PMID: 29142497
3. Expressions of CCR2 mRNA began to increase on the 1st day and reached to the peak on the 7th day, but then started to decrease gradually until 28th day. PMID: 26062549
4. Results suggest that CCL2/CCR2 in the dorsal root ganglion and spinal cord is involved in the maintenance of lumbar disc herniation-induced pain PMID: 24462503
5. investigated the expression changes and cellular localization of spinal CCR2 in a rat model of bone cancer induced by Walker 256 cell inoculation. expression of CCR2 in the spinal cord was significantly increased on day 6, 12, and 18 in bone cancer rats PMID: 23511129
6. Report functional roles for CCL2/CCR2 signaling at the level of the urinary bladder in reducing voiding frequency and somatic sensitivity following CYP-induced cystitis. PMID: 23594826
7. Overexpression of CCR2 in retinal microglia promotes their chemotaxis in response to chemokines. PMID: 23288990
8. CCR2 is involved in the process of mast cell degranulation in bladder tissues. PMID: 23049171
9. The IL-1beta and CCL2-CCR2 signaling cascades play a role in neuron-glia-cytokine interactions and the descending facilitation of neuropathic pain. PMID: 22466130
10. the important role of CCR2 in neuropathic pain PMID: 21143971
11. The expressions of CCR2 mRNA and protein increase significantly in cerebral tissue of newborn rat with hypoxic-ischemic brain damage. PMID: 18095591
12. The data show that CCR2 and CCL2 regulation in the hippocampus changes after pilocarpine-induced status epilepticus or seizures. These changes might be involved in detrimental neuroplasticity and neuroinflammatory changes that occur following seizures. PMID: 20034406
13. expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and its receptor in the testis of rats undergoing autoimmune orchitis PMID: 14638441
14. CCR1, CCR2, and CCR5 mRNA expression and tyrosine phosphorylation increased with peak inflammation in adjuvant induced arthritis PMID: 14674010
15. Cultured neural progenitor cells from the subventricular zone of adult rat brain express chemokine receptor CCR2. PMID: 14732474
16. Arterial wall and VSMC MCP-1/CCR2 increase with aging. MCP-1 enhances VSMC migration and invasion, and thus, MCP-1/CCR2 signaling may play a role in age-associated arterial remodeling. PMID: 15178559
17. IFNG priming enhances migration to inflammatory chemokines; IFN-gamma-inducible gene expression is attenuated by high levels of Stat1; physiological regulation of the relative abundance of Stat1 and Stat3 impacts on gene expression PMID: 16148108
18. MCP-1/CCR2 signaling is directly involved with a chronic compression injury and may contribute to associated neuronal hyperexcitability and neuropathic pain. PMID: 16174730
19. Data show that the preferential chemokine receptor (CCR)2 ligand, MCP-1/CCL2, elicits calcium transients in primary cultured neurons from various rat brain regions expressing CCR2. PMID: 16196033
20. CCR2 mediates recruitment of both infiltrating macrophages and resident microglia to specific sites of central nervous system inflammation. PMID: 17484785
21. These data suggest CCL2 and CCR2 as potential candidates for integrating inflammation and central neuropathic pain after spinal cord injury PMID: 18338959
22. CCR2 was also expressed in laser-induced CNV but did not increase after PDT. PMID: 18421085
23. Ccr2 is upregulated by injury to sensory neurons in the lumbar dorsal root ganglia and MCP-1/Ccr2 signaling contributes to subsequent changes in neural activity. These changes may contribute to neuropathic pain. PMID: 16174730

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Cell membrane; Multi-pass membrane protein.

G-protein coupled receptor 1 family

Expressed in lung, spleen, kidney, thymus and macrophages.

KEGG: rno:60463

UniGene: Rn.211983