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Rat Nuclear factor-kappa B(NF-κB) ELISA Kit

  • 中文名称：
    大鼠核因子κB(NF-κB)酶联免疫试剂盒
  • 货号：
    CSB-E13148r
  • 规格：
    96T/48T
  • 价格：
    ￥3800/￥2500
  • 其他：

产品详情

  • 产品描述：
        NFKB1（核因子κB亚单位1，Nuclear Factor Kappa B Subunit 1）是核因子κB（NF-κB）的亚单位之一，是一种转录因子，参与调控免疫和炎症反应。NFKB1的激活可以诱导多种免疫和炎症相关基因的表达，包括细胞因子、炎症介质等，从而促进炎症反应。NFKB1的异常表达与多种疾病的发生和发展相关。
        j9九游会登录入口首页生物所提供的Rat Nuclear factor-kappa B(NF-κB) ELISA Kit属于ELISA检测试剂盒，采用双抗夹心法定量检测大鼠血清、血浆、组织匀浆样本中的NFKB1，其灵敏度为0.39 pg/mL，检测范围为1.56 pg/mL-100 pg/mL。
     
  • 别名：
    Nfkb1 ELISA Kit; Nuclear factor NF-kappa-B p105 subunit ELISA Kit; DNA-binding factor KBF1 ELISA Kit; EBP-1 ELISA Kit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] ELISA Kit; Fragment ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
  • 检测范围：
  • 灵敏度：
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cell Biology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
     
  • 线性度：
     
  • 回收率：
     
  • 标准曲线：
     
  • 数据处理：
  • 货期：
    3-5 working days

引用文献

产品评价

问答及客户评论

■ 常见问题解答
Q:

How can I convert pyggrams per decilitre to picograms per milligram, because your kits are in deciliters and concentrates
picogeram/dl---picogeram/mg
this kits according to picogerm/dl, i want according to picogeram /mg

A:
Thanks for your inquiry. For the kit indicated,convertions are not suggested.We recommand you caculate according to the unit stated in the manual.
Pls let me know if you have any further questions. Thank you.

靶点详情

  • 最新研究进展：
    NFKB1是一种转录因子，能够介导炎症、免疫反应、细胞生长和凋亡等多种生物学过程。最新的研究发现，NFKB1在人类疾病的发生和发展中发挥着重要作用。例如，研究人员发现NFKB1在肿瘤的发生和转移中发挥了重要作用，并且抑制NFKB1的活性可以抑制肿瘤的生长。此外，NFKB1也参与了许多自身免疫性疾病的发生和发展，如类风湿性关节炎和炎症性肠病等。
  • 功能：
    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis. Isoform 5, isoform 6 and isoform 7 act as inhibitors of transactivation of p50 NF-kappa-B subunit, probably by sequestering it in the cytoplasm. Isoform 3 (p98) (but not p84 or p105) acts as a transactivator of NF-kappa-B-regulated gene expression. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 数据库链接：