ADCY7 Antibody
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货号:CSB-PA006812
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规格:¥880
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其他:
产品详情
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Uniprot No.:P51828
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基因名:
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别名:ADCY7 antibody; KIAA0037Adenylate cyclase type 7 antibody; EC 4.6.1.1 antibody; ATP pyrophosphate-lyase 7 antibody; Adenylate cyclase type VII antibody; Adenylyl cyclase 7 antibody
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宿主:Rabbit
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反应种属:Human,Mouse
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免疫原:Synthesized peptide derived from the Internal region of Human A Cyclase VII.
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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产品提供形式:Liquid
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应用范围:IHC, IF, ELISA
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推荐稀释比:
Application Recommended Dilution IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha c...显示更多
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基因功能参考文献:
- We discovered a 0.6% frequency missense variant in ADCY7. PMID: 28067910
- The stronger TNF-alpha responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 and ADCY9. PMID: 25959651
- The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients. PMID: 26220344
- evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression. PMID: 22264442
- we found that single nucleotide polymorphisms in ADCY7 associate with alcohol dependence in women, and these markers are also associated with ADCY7 expression (messenger RNA) levels. PMID: 21481845
- construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase PMID: 11665607
- The first cytoplasmic domain (residues 506-584) of adenylyl cyclase (AC) type VII is an internal regulatory subunit, interacting with a cardinal activator of AC (Gs alpha) and with the conserved first catalytic domain of type VII AC. PMID: 15581358
- Brain type VII adenylyl cyclase isoform plays a sex-specific role in the manifestation of a heritable form of depressive symptoms in genetically modified mice. PMID: 17135423
- AC7 is a specific downstream effector of the G(12/13) pathway PMID: 18541530
- soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion PMID: 19008230
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亚细胞定位:Membrane; Multi-pass membrane protein.
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蛋白家族:Adenylyl cyclase class-4/guanylyl cyclase family
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数据库链接:
HGNC: 238
OMIM: 600385
KEGG: hsa:113
STRING: 9606.ENSP00000254235
UniGene: Hs.513578