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ADCY7 Antibody

  • 货号:
    CSB-PA006812
  • 规格:
    ¥880
  • 其他:

产品详情

  • Uniprot No.:
    P51828
  • 基因名:
  • 别名:
    ADCY7 antibody; KIAA0037Adenylate cyclase type 7 antibody; EC 4.6.1.1 antibody; ATP pyrophosphate-lyase 7 antibody; Adenylate cyclase type VII antibody; Adenylyl cyclase 7 antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human A Cyclase VII.
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated
  • 抗体亚型:
    IgG
  • 纯化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式:
    Liquid
  • 应用范围:
    IHC, IF, ELISA
  • 推荐稀释比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能:
    Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha c...显示更多
  • 基因功能参考文献:
    1. We discovered a 0.6% frequency missense variant in ADCY7. PMID: 28067910
    2. The stronger TNF-alpha responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 and ADCY9. PMID: 25959651
    3. The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients. PMID: 26220344
    4. evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression. PMID: 22264442
    5. we found that single nucleotide polymorphisms in ADCY7 associate with alcohol dependence in women, and these markers are also associated with ADCY7 expression (messenger RNA) levels. PMID: 21481845
    6. construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase PMID: 11665607
    7. The first cytoplasmic domain (residues 506-584) of adenylyl cyclase (AC) type VII is an internal regulatory subunit, interacting with a cardinal activator of AC (Gs alpha) and with the conserved first catalytic domain of type VII AC. PMID: 15581358
    8. Brain type VII adenylyl cyclase isoform plays a sex-specific role in the manifestation of a heritable form of depressive symptoms in genetically modified mice. PMID: 17135423
    9. AC7 is a specific downstream effector of the G(12/13) pathway PMID: 18541530
    10. soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion PMID: 19008230

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  • 亚细胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 数据库链接:

    HGNC: 238

    OMIM: 600385

    KEGG: hsa:113

    STRING: 9606.ENSP00000254235

    UniGene: Hs.513578