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ATP6V1A Antibody

  • 货号：
    CSB-PA002396GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P38606
  • 基因名：
  • 别名：
    70kDa subunit antibody; ATP6A1 antibody; ATP6V1A antibody; ATP6V1A1 antibody; ATPase H+ transporting lysosomal subunit A1 antibody; ATPase H+ transporting; lysosomal 70kDa V1 subunit A antibody; H(+) transporting two sector ATPase subunit A antibody; H+ transporting ATPase chain A vacuolar (VA68 type) antibody; HO68 antibody; OTTHUMP00000214746 antibody; V ATPase 69 kDa subunit 1 antibody; V ATPase A subunit 1 antibody; V ATPase subunit A 1 antibody; V-ATPase 69 kDa subunit antibody; V-ATPase subunit A antibody; V-type proton ATPase catalytic subunit A antibody; VA68 antibody; Vacuolar ATP synthase catalytic subunit A ubiquitous isoform antibody; Vacuolar ATPase isoform VA68 antibody; Vacuolar proton pump alpha subunit 1 antibody; Vacuolar proton pump subunit alpha antibody; VATA_HUMAN antibody; Vma1 antibody; VPP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ATP6V1A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity.; (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction.
  • 基因功能参考文献：
    1. We report biallelic mutations in ATP6V1E1 and ATP6V1A, respectively encoding the E1 and A subunits of the V1 domain of V-ATPase, as a cause of distinct metabolic and multisystemic cutis laxa entities. PMID: 28065471
    2. V1A subunit of V-ATPase has a role in the progression and prognosis of gastric cancer. PMID: 25652905
    3. Data show that the cAMP/PKA/CREB signaling pathway initiates acidosis-induced V-ATPase trafficking in salivary ducts via regulation of Rab11b expression. PMID: 22561749
    4. These data introduce Rab11b as a crucial regulator and Rip11 as mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland. PMID: 20717956
    5. there is an important role for physical association between aldolase and the A, B and E subunits of V-ATPase in the regulation of the proton pump PMID: 17576770

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  • 相关疾病：
    Cutis laxa, autosomal recessive, 2D (ARCL2D)
  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, secretory vesicle.
  • 蛋白家族：
    ATPase alpha/beta chains family
  • 组织特异性：
    High expression in the skin.
  • 数据库链接：

    HGNC: 851

    OMIM: 607027

    KEGG: hsa:523

    STRING: 9606.ENSP00000273398

    UniGene: Hs.477155