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ATP6V1C1 Antibody

  • 货号：
    CSB-PA002399LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA002399LA01HU diluted at 1:100 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA002399LA01HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of MCF-7 cells with CSB-PA002399LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATP6V1C1 Polyclonal antibody
  • Uniprot No.：
    P21283
  • 基因名：
  • 别名：
    ATP6C antibody; ATP6D antibody; ATP6V1C1 antibody; ATPase H+ transporting lysosomal (vacuolar proton pump) 42kD antibody; ATPase H+ transporting lysosomal 42kD V1 subunit C isoform 1 antibody; ATPase H+ transporting lysosomal 42kDa V1 subunit C isoform 1 antibody; ATPase H+ transporting lysosomal 42kDa V1 subunit C1 antibody; ATPase H+ transporting lysosomal V1 subunit C1 antibody; FLJ20057 antibody; H(+) transporting two sector ATPase subunit C antibody; H+ ATPase C subunit antibody; H+ transporting ATPase chain C vacuolar antibody; Subunit C of vacuolar proton ATPase V1 domain antibody; V ATPase C subunit antibody; V ATPase subunit C 1 antibody; V-ATPase subunit C 1 antibody; V-type proton ATPase subunit C 1 antibody; Vacuolar ATP synthase subunit C antibody; Vacuolar proton pump 42 kD subunit antibody; Vacuolar proton pump C subunit antibody; Vacuolar proton pump subunit C 1 antibody; Vacuolar protonATPase subunit C VI domain antibody; VATC antibody; VATC1_HUMAN antibody; VATPase C subunit antibody; VATPase subunit C 1 antibody; VMA5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human V-type proton ATPase subunit C 1 protein (129-382AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ATP6V1C1 Antibody (CSB-PA002399LA01HU)，的标记方式是Non-conjugated。对于ATP6V1C1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002399LB01HU ATP6V1C1 Antibody, HRP conjugated ELISA
    FITC CSB-PA002399LC01HU ATP6V1C1 Antibody, FITC conjugated
    Biotin CSB-PA002399LD01HU ATP6V1C1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
  • 基因功能参考文献：
    1. knockdown of C1 reduces breast cancer growth, metastasis, and osteolytic lesion formation. PMID: 28504970
    2. We assessed ATPaseC1 expression in a sample of oral squamous cell carcinoma using tissue microarrays to analyze the relation between ATPaseC1 expression and clinical, histopathological and prognostic parameters. PMID: 25901422
    3. results of our study suggest that high expression of Atp6v1c1 affects the actin structure of cancer cells such that it facilitates breast cancer metastasis PMID: 24454753
    4. Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa. PMID: 21526910
    5. proximal promoter region contains cis-acting elements required for expression in cancer cells PMID: 12890556

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  • 蛋白家族：
    V-ATPase C subunit family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 856

    OMIM: 603097

    KEGG: hsa:528

    STRING: 9606.ENSP00000379203

    UniGene: Hs.86905