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CACNA1E Antibody

  • 货号：
    CSB-PA942999
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA942999(CACNA1E Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA942999(CACNA1E Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q15878
  • 基因名：
  • 别名：
    alpha-1 polypeptide antibody; BII antibody; Brain calcium channel II antibody; CAC 1E antibody; CAC1E antibody; CAC1E_HUMAN antibody; CACH 6 antibody; CACH6 antibody; CACNA1E antibody; Cacnl1 a6 antibody; CACNL1A6 antibody; Calcium channel antibody; Calcium channel; L type; alpha 1 polypeptide; isoform 6 antibody; calcium channel; R type antibody; Cav 2.3 antibody; Cchra 1 antibody; Cchra1 antibody; isoform 6 antibody; L type antibody; Voltage dependent R type calcium channel subunit alpha 1E antibody; Voltage gated calcium channel subunit alpha Cav2.3 antibody; Voltage-dependent R-type calcium channel subunit alpha-1E antibody; Voltage-gated calcium channel subunit alpha Cav2.3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CACNA1E
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
  • 基因功能参考文献：
    1. This study identified a polymorphism in exon 20 of the CACNA1E gene (Asp859Glu - rs35737760) that is more prevalent in hemiplegic and brain stem aura migraine. PMID: 28573794
    2. Carriers of the minor G allele of the rs3845446 SNP exhibited enhanced pain-related phenotypes after gastrointestinal surgery. The pain-related phenotypes of carriers of the minor allele of this SNP after gastrointestinal surgery were opposite to such phenotypes after orthognathic surgery. PMID: 27480382
    3. Data suggest that, in vascular smooth muscle cells, increase in cytosolic endothelin-1 (EDN1) induces sustained increase in nuclear Ca2+ via stimulation of R-type calcium channel (CACNA1E) present at the nuclear membrane. PMID: 25741585
    4. CACNA1E gene single nucleotide polymorphisms may be involved in fentanyl sensitivity. PMID: 23940630
    5. The C-terminus of human Ca(v)2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines PMID: 22633975
    6. quartet of leucine residues in the guanylate kinase domain of CaVbeta determines the plasma membrane density of the CaV2.3 channel. PMID: 22846999
    7. CACNA1E variants affect beta cell function in patients with newly diagnosed type 2 diabetes. PMID: 22427875
    8. the II-III loop of the Ca(v)2.3 calcium channel binds APLP1 and that this binding promotes internalization of the channel PMID: 22178872
    9. Ca(v)2.3 Ca2+ channel interacts with the G1-subunit of V-ATPase. PMID: 21691059
    10. Lack of high-voltage activated Cav2.3 channels results in a marked decrease in the sensitivity of transgenic animals to gamma-butyrolactone-induced absence epilepsy. PMID: 21482359
    11. Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes. PMID: 20026913
    12. Review discusses the roles of Cav2.3-containing E-type Ca2+ channels which exhibit several subunit-specific features, trigger exocytosis and are also involved in long-term potentiation. PMID: 15845089
    13. Full-length RGS3, RGS3T, and the core domain of RGS3 were equally effective in antagonizing inhibition of Ca(V)2.3 through M(2)R. PMID: 16855219
    14. Neurokinin 1 receptorsmodulate CaV2.3 using three different signaling mechanisms: a fast inhibition mediated by Gbeta gamma, a slow inhibition mediated by Galpha(q/11), and a slow stimulation mediated by protein kinases C. PMID: 17050807
    15. Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors. PMID: 17189400
    16. analysis of a three-dimensional homology model of Ca(V)2.3 based upon Kv1.2 where hydrophobic residues at positions facing Val(1720) in IS6, IIS6, and IIIS6 play a critical role in stabilizing the closed state in Ca(V)2.3 PMID: 17660294
    17. A functional variant in CACNA1E contributes to type 2 diabetes susceptibility in Pima indians by affecting insulin action. PMID: 17720895
    18. Genetic variation in the CACNA1E gene contributes to an increased risk of the development of type 2 diabetes by reducing insulin secretion. PMID: 17934712
    19. These findings strongly suggest that both H179 and H183 in the IS3-IS4 loop are essential structural determinants required for nickel sensitive inhibition of the Cav2.3. PMID: 18037383

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1E subfamily
  • 组织特异性：
    Expressed in neuronal tissues and in kidney.
  • 数据库链接：

    HGNC: 1392

    OMIM: 601013

    KEGG: hsa:777

    STRING: 9606.ENSP00000356545

    UniGene: Hs.437444