CALML3 Antibody
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货号:CSB-PA004453DSR1HU
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规格:¥440
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促销:
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图片:
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Western blot
All lanes: CALML3 antibody at 1.44µg/ml + A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa -
Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA004453DSR1HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA004453DSR1HU at dilution of 1:100
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) CALML3 Polyclonal antibody
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Uniprot No.:P27482
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基因名:
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别名:CALL3_HUMAN antibody; CALML3 antibody; Calmodulin like 3 antibody; Calmodulin related protein NB 1 antibody; Calmodulin-like protein 3 antibody; Calmodulin-related protein NB-1 antibody; CaM like protein antibody; CaM-like protein antibody; CLP antibody; OTTHUMP00000019004 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Calmodulin-like protein 3 protein (1-149AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.
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基因功能参考文献:
- Metformin suppresses gastric cancer through stimulating Calml3 secretion from TAFs. PMID: 30320344
- UVB irradiation induced increase in apoptosis, Reactive Oxygen Species production and Ca2+ concentration of human lens epithelial cells , in part, by downregulating the expression of CALML3 and involved oxidative stress, Ca2+, JNK1/2 and ERK1/2 signaling pathways, suggesting that investigating CALML3 may useful for developing cataract treatment. PMID: 29436594
- We identified calmodulin-like protein 3 (CALML3) as a key sensor of this SNP and a coregulator of ERalpha, which contributes to differential gene transcription regulation in an estrogen and SERM-dependent fashion. Furthermore, using CRISPR/Cas9-engineered ZR75-1 breast cancer cells with different ZNF423 SNP genotypes, striking differences in cellular responses to SERMs and PARP inhibitors, alone or in combination PMID: 28821270
- Loss of CALML3 predicts shorter overall and relapse-free survival in postoperative hepatocellular carcinoma (HCC) patients, thus providing a prognostic biomarker and therapy target in HCC. PMID: 29445139
- Increased CALML3 expression in suprabasal layers is characteristic for differentiating keratinocytes in normal epidermis, and nuclear expression of CALML3 inversely correlates with expression of the proliferation marker Ki-67. PMID: 23638045
- CLP may be required during terminal differentiation to increase myosin-10 function as cells migrate toward the upper layers and establish new adhesive contacts. PMID: 17130134
- increased CLP expression and CLP-mediated Myo10 function are important for skin differentiation and wound reepithelialization PMID: 18818677
- expression was readily detected in areas of normal oral mucosa, while a notable downregulation of expression occurred in areas of malignant transformation PMID: 19166543
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蛋白家族:Calmodulin family
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组织特异性:Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells.
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数据库链接:
HGNC: 1452
OMIM: 114184
KEGG: hsa:810
STRING: 9606.ENSP00000315299
UniGene: Hs.239600
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