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CCNB2 Antibody

  • 货号：
    CSB-PA004808LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate
      All lanes: CCNB2 antibody at 2.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46 kDa
      Observed band size: 46 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA004808LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCNB2 Polyclonal antibody
  • Uniprot No.：
    O95067
  • 基因名：
  • 别名：
    ccnb2 antibody; CCNB2_HUMAN antibody; CycB2 antibody; Cyclin B2 antibody; G2 mitotic specific cyclin B2 antibody; G2/mitotic specific cyclin B2 antibody; G2/mitotic-specific cyclin-B2 antibody; HsT17299 antibody; MGC108931 antibody; MGC140694 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human G2/mitotic-specific cyclin-B2 protein (7-163AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CCNB2 Antibody (CSB-PA004808LA01HU)，的标记方式是Non-conjugated。对于CCNB2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004808LB01HU CCNB2 Antibody, HRP conjugated ELISA
    FITC CSB-PA004808LC01HU CCNB2 Antibody, FITC conjugated
    Biotin CSB-PA004808LD01HU CCNB2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for the control of the cell cycle at the G2/M (mitosis) transition.
  • 基因功能参考文献：
    1. Data show that Islet-1 (ISL1) activated the expression of cyclin B1 (CCNB1), cyclin B2 (CCNB2) and c-myc (c-MYC) genes by binding to the conserved binding sites on their promoters or enhancers. PMID: 27183908
    2. Data show that the cyclin B2 was overexpressed in bladder cancer tissue. PMID: 26706119
    3. overexpression of CCNB2 protein is associated with clinical progression and poor prognosis in non-small cell lung cancer PMID: 26349989
    4. Cyclin B1 and cyclin B2 are interchangeable for ability to promote G2 and M transition in HeLa cells. PMID: 24324638
    5. there was no significance in the 5-year overall survival rates among the patients with squamous cell carcinoma between expressing lower and higher level of cyclin B2 mRNA PMID: 24375198
    6. Suggest that cytoplasmic CCNB2 may function as an oncogene and could serve as a potential biomarker of unfavorable prognosis over short-term follow-up in breast cancer. PMID: 23282137
    7. The relative expression level of circulating CCNB2 mRNA in cancer patients was significantly higher than that in normal controls and benign diseases group. Circulating CCNB2 mRNA level significantly correlated with cancer stage and metastasis status. PMID: 21161946
    8. Data suggest that cyclin A2 helps initiate mitosis, in part through its effects on cyclin B1, and that cyclins B1 and B2 are particularly critical for the maintenance of the mitotic state. PMID: 20660152
    9. Overexpression of B-type cyclins alters chromosomal segregation PMID: 11960377
    10. p300 binds to multiple NF-Y trimers to regulate cyclin B2 promoter function PMID: 12482752
    11. cyclin B2 expression in colorectal adenocarcinoma is dependent on NF-Y PMID: 17289878
    12. severe reduction by separate RNA interference of either cyclin B1 or cyclin B2 protein levels results in little or no alteration of the cell cycle and, more specifically, of mitosis progression PMID: 17533373
    13. This gene may be used as a very reliable biomarker of lung adenocarcinoma. PMID: 17549666

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  • 蛋白家族：
    Cyclin family, Cyclin AB subfamily
  • 数据库链接：

    HGNC: 1580

    OMIM: 602755

    KEGG: hsa:9133

    STRING: 9606.ENSP00000288207

    UniGene: Hs.194698