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CER1 Antibody

  • 货号：
    CSB-PA005254ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Cerberus antibody at 2μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Rat kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 30 kDa
      Observed band size: 30 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CER1 Polyclonal antibody
  • Uniprot No.：
    O95813
  • 基因名：
  • 别名：
    CER 1 antibody; cer1 antibody; CER1_HUMAN antibody; Cerberus 1 (Xenopus laevis) homolog (cysteine knot superfamily) antibody; Cerberus 1 antibody; Cerberus 1 cysteine knot superfamily homolog (Xenopus laevis) antibody; Cerberus antibody; Cerberus related 1 antibody; Cerberus related protein antibody; Cerberus-related protein antibody; Cerberus1 antibody; DAN domain family member 4 antibody; DAND 4 antibody; DAND4 antibody; MGC119894 antibody; MGC119895 antibody; MGC96951 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Cerberus protein (18-267AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.
  • 基因功能参考文献：
    1. Cerberus binds and inhibits Nodal, Activin B, BMP-6, and BMP-7 but not BMP-2 or Activin A. PMID: 26802359
    2. No significant association between the studied DKK1 variations and osteoporosis was found, while CER1 variations seem to play a significant role in the determination of osteoporosis, combined with bone markers, in postmenopausal osteoporotic women. PMID: 24138842
    3. results show that Cer1 (or CER1) serves as a good marker for quantification of definitive endoderm differentiation of mouse and human ES/iPS cells PMID: 23717584
    4. CER1 gene variations play a significant role in determining BMD and vertebral or hip fractures, which might be helpful in clinical practice to identify patients with increased fracture risk PMID: 22543871
    5. functional candidate gene for trigonocephaly PMID: 18452192
    6. successful identification of an association with CER1 in humans together with our mouse study suggests that CER1 may play a role in the development of bone or its metabolism PMID: 19113921

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    DAN family
  • 数据库链接：

    HGNC: 1862

    OMIM: 603777

    KEGG: hsa:9350

    STRING: 9606.ENSP00000370297

    UniGene: Hs.248204