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GABBR1 Antibody

  • 货号：
    CSB-PA106396
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human brain tissue using GABA B Receptor antibody.
    • Western blot analysis of extracts from HeLa cells, using GABA B Receptor antibody.
    • Western blot analysis of extracts from JK cells (Lane 2) and A549 cells (Lane 3), using GABA-B Receptor antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GABBR1 Polyclonal antibody
  • Uniprot No.：
    Q9UBS5
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human GABA B receptor.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.; Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.
  • 基因功能参考文献：
    1. GABA B receptor expression in myometrium PMID: 30343129
    2. Results show that pregnancy anxiety is associated with differential DNA methylation patterns in newborns and, reveal a potential role for GABBR1 methylation in association with stress in newborns. PMID: 29026448
    3. GABAB receptor modulation in Periodontal Ligament cells might become an important target in immunoinflammatory settings. PMID: 27812916
    4. There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene. PMID: 28118741
    5. The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87). PMID: 27922604
    6. Genotype and allele frequencies of rs29230 in GABR1 were significantly different between cases and controls, especially for male patients, for obstructive sleep apnea risk in Chinese Han population. PMID: 27509181
    7. presynaptic gamma-aminobutyric acid type B receptor deficits contribute to altered neuronal excitability in fragile X syndrome PMID: 28213518
    8. Results show that GABBR1 minor genotypes/alleles were protective against risk for alcoholism in 3 ethnically diverse cohorts. PMID: 26727527
    9. Cell surface ubiquitination precedes endocytosis, after which USP14 acts as an ubiquitin-binding protein that targets the ubiquitinated GABA B receptor to lysosomal degradation and promotes its deubiquitination. PMID: 26817839
    10. GABA(B)R stimulation promotes chemotaxis in RBL cells which is dependent on signaling via PI3-K/Akt, Src kinases and on rearrangement of both microtubules and actin cytoskeleton. PMID: 25725285
    11. GABBR1 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2+)]i via a Gi/o-coupled receptor pathway and a phospholipase C activation pathway. PMID: 24682435
    12. the first report of abnormal levels of GABA+ and Glx in mood-related brain regions of women with PMDD, indicating that dysregulation of the amino acid neurotransmitter system may be an important neurobiological mechanism in the pathogenesis of PMDD. PMID: 25465316
    13. Chronic alcohol altered exon/intron expression and splice junction levels. PMID: 24209778
    14. GABBR1 protein involved in phenylthiourea bitter taste detection. PMID: 24006265
    15. The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation. PMID: 24778228
    16. s suggest GABBR1, GABA receptor B1, is implicated in schizophrenia based on a Human endogenous retrovirus long terminal repeat (HERV-W LTR) in the regulatory region of GABBR1. PMID: 23391219
    17. GABA may inhibit the growth of cholangiocarcinoma QBC939 cells through the GABAB receptor, and the anti-cancer effects may be partly mediated via the JAK/STAT3 pathway PMID: 23007731
    18. Activation of GABA(B) receptors significantly inhibits Akt/GSK-3 signaling in a beta-arrestin-dependent pathway. PMID: 23192081
    19. We have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors which seem to come from immunoglobulin chains and appear also as homologies in receptor heteromers. PMID: 21932037
    20. Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. PMID: 22613715
    21. This study does not support that GBR1 is involved in essential tremor. PMID: 22321358
    22. Long interval intracortical inhibition is significantly reduced and the cortical silent period is significantly shortened in patients with succinic semialdehyde dehydrogenase (SSADH) deficiency compared to heterozygous parents and control groups. PMID: 22722631
    23. The GBR2 ectodomain directly interacts with the GBR1 ectodomain to increase agonist affinity by selectively stabilizing the agonist-bound conformation of GBR1. PMID: 22660477
    24. The present meta-analysis suggests that GABBR1 G1465A polymorphism is associated with the risk of temporal lobe epilepsy. PMID: 21621395
    25. The results of this study provided evidence of Gabbr1 Deficit in schizophrenia and mood disorders. PMID: 21303731
    26. Data suggest that the GABAB1 intron 4 containing N-terminal truncation is necessary for the inhibitory action of the new splice variants. PMID: 21124972
    27. This chapter summarizes current understanding of the molecular function of the GABA(B) receptor and recent developments in the identification of allosteric modulators. PMID: 20655478
    28. This chapter focuses on the recently emerged mechanisms of GABA(B) receptor exocytosis, endocytosis, recycling, and degradation. PMID: 20655479
    29. The role that this phosphorylation plays in determining GABA(B)R effector coupling and their trafficking within the endocytic pathway, is discussed. PMID: 20655480
    30. The relationships between the GABA(B) receptor, its effectors and associated proteins that mediate GABA(B) receptor function within the brain, is described. PMID: 20655481
    31. Current knowledge on a new role of GABA(B)R as an ambience-dependent regulator of synaptic signaling, is presented. PMID: 20655482
    32. This chapter reviews data suggesting that neurogliaform cells produce electrophysiological effects onto other neurons in the cortical cell network via GABA(B)R-mediated volume transmission that is highly regulated by GAT1 activity. PMID: 20655483
    33. The overexpression of one particular gene encoding for G-protein-activated inward rectifying potassium type 2 (GIRK2) channel subunit and its coupling to GABA(B) receptors may contribute to a range of mental and functional disabilities in Down syndrome. PMID: 20655490
    34. Significant reductions in GABA(B) receptor subunit 1 density are demonstrated in cingulate cortex and fusiform gyrus from patients with autism compared to controls. PMID: 20557420
    35. GABAB1 subunits interact with DGCR6 in the endoplasmic reticulum prior to their recruitment into functional GABAB receptors. PMID: 20036641
    36. Data show that GABA is a potent chemoattractant of HUCB stem/progenitor cells specifically through GABA(B)R activation. PMID: 19327013
    37. variants of GABBR1 and GABBR2 are associated with nicotine dependence in European- and African-American populations PMID: 19763258
    38. Alterations in inhibitory synaptic transmission through GABA(B)R1 appears to affect differentially certain hippocampal circuits in a population of epileptic patients and could contribute to the pathophysiology of temporal lobe epilepsy. PMID: 12115687
    39. The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor. PMID: 12130687
    40. evidence that the translated polymorphism of exon 7 may be functionally meaningful and impact cortical EEG oscillations PMID: 12555235
    41. The GABA(B[1]) polymorphism (G1465A) confers a highly increased susceptibility to temporal lobe epilepsy. Moreover, it seems to influence the severity of this common epileptic disorder PMID: 12601092
    42. Post hoc analyses showed an association between EEG phenotype and exon 7 genotype in normal subjects only. PMID: 12645817
    43. GABBR1 gene might not be a susceptibility gene for childhood absence epilepsy at least in the Chinese population PMID: 12770685
    44. GHB, administered in vivo, reduces MAP kinase phosphorylation via a direct activation of GABAB receptors by GHB, but was found ineffective on MAP kinase phosphorylation in brain slices PMID: 12923192
    45. Increased expression of GABA(B) receptor subtype 1 indicates augmented presynaptic inhibition of glutamate release as a possible protective mechanism in temporal lobe epilepsy. PMID: 14625043
    46. Altered GABA(B1a) receptor mRNA expression occurs in human temporal lobe epilepsy; possibly the observed changes may also serve to counteract ongoing hyperexcitability. PMID: 14643764
    47. GABAB receptor cell surface stability is modulated by phosphorylation and chronic agonist treatment PMID: 14707142
    48. GABA(B) receptor subunit GABA(B)R1 is found on the same neurons and follows the same distribution patterns in the basal ganglia as the GABABR2 receptor subunit. PMID: 14961561
    49. Association of the GABA(B)R1 with the GABA(A) receptor gamma2S subunit robustly promotes cell surface expression of GABA(B)R1 in the absence of GABA(B)R2, that is usually required for efficient trafficking of GABA(B)R1 to the cell surface. PMID: 14966130
    50. The GABA(B) receptor may be present as a heterodimer with subunits of GABA(B1) and GABA(B2) in the human colon. PMID: 14978362

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite.; [Isoform 1E]: Secreted.
  • 蛋白家族：
    G-protein coupled receptor 3 family, GABA-B receptor subfamily
  • 组织特异性：
    Highly expressed in brain. Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer. Isoform 1B: Mainly expressed in Purkinje cells. Isoform 1E: Predominantly expressed in peripheral tissues
  • 数据库链接：

    HGNC: 4070

    OMIM: 603540

    KEGG: hsa:2550

    STRING: 9606.ENSP00000366233

    UniGene: Hs.167017