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GPR126 Antibody

  • 货号：
    CSB-PA002202
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using DREG Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q86SQ4
  • 基因名：
  • 别名：
    adhesion G protein coupled receptor G6 antibody; APG1 antibody; Developmentally regulated G protein coupled receptor antibody; Developmentally regulated G-protein-coupled receptor antibody; dj287g14.2 antibody; DREG antibody; G protein coupled receptor 126 antibody; G-protein coupled receptor 126 antibody; GP126_HUMAN antibody; GPR126 antibody; HBV PreS1 transactivated protein 2 antibody; HBV PreS1-transactivated protein 2 antibody; LCCS9 antibody; OTTHUMP00000017320 antibody; OTTHUMP00000237093 antibody; OTTHUMP00000237094 antibody; OTTHUMP00000237115 antibody; PR126 antibody; Probable G protein coupled receptor 126 [Precursor] antibody; Probable G protein coupled receptor 126 antibody; Probable G-protein coupled receptor 126 [Precursor] antibody; Probable G-protein coupled receptor 126 antibody; PS1TP2 antibody; Vascular inducible G protein coupled receptor antibody; Vascular inducible G protein-coupled receptor antibody; VIGR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human DREG.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis.
  • 基因功能参考文献：
    1. The association of a single nucleotide polymorphism in GPR126 with aggressive periodontitis in a Japanese population. The role of GPR126 in maintaining the homeostasis of periodontal ligament tissues. PMID: 27509131
    2. Together, these data uncover Gpr126 as a genetic cause for the pathogenesis of Adolescent idiopathic scoliosis (AIS) and pectus excavatum in a mouse model. PMID: 25954032
    3. Genetic variants of GPR126 gene are associated with adolescent idiopathic scoliosis susceptibility in Chinese populations. PMID: 25479386
    4. Mutations of GPR126 are responsible for severe arthrogryposis multiplex congenita. PMID: 26004201
    5. GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling PMID: 25217645
    6. Gpr126 functions in Schwann cells for proper development and myelination through G-protein-signaling pathways. PMID: 24227709
    7. A single nucleotide polymorphism in the GPR126 gene is associated with increased susceptibility for adolescent idiopathic scoliosis. [Meta-analysis] PMID: 23666238
    8. Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms. PMID: 21929287
    9. The PS1TP2 gene was located at 6q24.1, and interacts with leukocyte proteins. PMID: 18304421
    10. VIGR represents a novel G protein coupled receptors of the adhesion family, which is unique in its long extra-cellular domain. PMID: 15225624
    11. APG1 formed an alpha-helical structure at the C-terminal site and a positive charge cluster at the N-terminal site. PMID: 17109822

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  • 相关疾病：
    Lethal congenital contracture syndrome 9 (LCCS9)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 组织特异性：
    Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
  • 数据库链接：

    HGNC: 13841

    OMIM: 606255

    KEGG: hsa:57211

    STRING: 9606.ENSP00000356581

    UniGene: Hs.743302