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GRM8 Antibody

  • 货号：
    CSB-PA232728
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR8 antibody.
    • Western blot analysis of extracts from mouse brain, using GluR8 antibody.
    • Western blot analysis of extracts from k562 cells (Lane 2), using mGluR8 antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GRM8 Polyclonal antibody
  • Uniprot No.：
    O00222
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human GluR8.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
  • 基因功能参考文献：
    1. This study showed that GRM8 was nominally associated (p < 0.05) with both delta measures (energy and intertrial phase coherence). PMID: 27871913
    2. These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence. PMID: 25978827
    3. Genome wide association study and meta-analysis results detected rs6951643, a GRM8 genetic variant as suggestive marker for sporadic Creutzfeldt-Jakob disease risk mapping outside the PRNP region. PMID: 25918841
    4. propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1, and GRM8). PMID: 24821406
    5. The GRM8 gene might play an important role in the pathogenesis of schizophrenia. PMID: 25588301
    6. Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain PMID: 23420844
    7. Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP. PMID: 21493956
    8. Pias1 binds to and sumoylates metabotropic glutamate receptor 8 PMID: 16144832
    9. GRM8 genes are likely involved in the pathogenesis of autistic disorder. PMID: 17955477
    10. Association of suingle nucleotide polymorphisms in GRM8 with theta power of event-related oscillations and alcohol dependence are reported. PMID: 18618593

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 数据库链接：

    HGNC: 4600

    OMIM: 601116

    KEGG: hsa:2918

    STRING: 9606.ENSP00000344173

    UniGene: Hs.449625