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NS Antibody

  • 货号：
    CSB-PA356065LA01IIE
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Influenza A virus NS Polyclonal antibody
  • Uniprot No.：
    P03495
  • 基因名：
    NS
  • 别名：
    NS antibody; Non-structural protein 1 antibody; NS1 antibody; NS1A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Influenza A virus
  • 免疫原：
    Recombinant Influenza A virus Non-structural protein 1 protein (152-237AA)
  • 免疫原种属：
    Influenza A virus
  • 标记方式：
    Non-conjugated

    本页面中的产品，NS Antibody (CSB-PA356065LA01IIE)，的标记方式是Non-conjugated。对于NS Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA356065LB01IIE NS Antibody, HRP conjugated ELISA
    FITC CSB-PA356065LC01IIE NS Antibody, FITC conjugated
    Biotin CSB-PA356065LD01IIE NS Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.; Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA.
  • 亚细胞定位：
    Host nucleus. Host cytoplasm.
  • 蛋白家族：
    Influenza A viruses NS1 family