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PPP2R1B Antibody

  • 货号：
    CSB-PA003833
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using PP2A-Aβ Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P30154
  • 基因名：
  • 别名：
    2AAB_HUMAN antibody; beta isoform of regulatory subunit A; protein phosphatase 2 antibody; PP2A A beta antibody; PP2A subunit A isoform PR65-beta antibody; PP2A subunit A isoform R1-beta antibody; PP2A; subunit A; PR65 beta isoform antibody; PP2A; subunit A; R1 beta isoform antibody; PPP2R1B antibody; PPP4R1 antibody; PR65B antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); beta isoform antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A; beta isoform antibody; Protein phosphatase 2; regulatory subunit A; beta antibody; Protein phosphatase 2; structural/regulatory subunit A; beta antibody; protein phosphatase 2; structural/regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A; 65 kDa regulatory subunit A; beta isoform antibody; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human PP2A-Aβ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IHC 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
  • 基因功能参考文献：
    1. MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. PMID: 26247730
    2. For PPP2R1B, no mutations were detected in our samples. PMID: 23588898
    3. Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B. PMID: 21420167
    4. Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues. PMID: 20133745
    5. apoptosis mediated by Fas, TNF-alpha, and TRAIL in U937 cells is suppressed by calyculin A, an inhibitor of type-1 and type-2A protein phosphatases PMID: 14576831
    6. PPP2R1B has a role in regulating activity of specific downstream target proteins for cell cycle regulation in colorectal cancers PMID: 14767517
    7. Functional interaction between PR65, a regulatory subunit of the protein phosphatase 2A (PP2A), and CFTR was shown. PMID: 15936019
    8. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC. PMID: 17324501
    9. PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer. PMID: 17343570
    10. PPP2R1B, together with NPAT and CUL5, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
    11. These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. PMID: 17540176

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  • 蛋白家族：
    Phosphatase 2A regulatory subunit A family
  • 数据库链接：

    HGNC: 9303

    OMIM: 603113

    KEGG: hsa:5519

    STRING: 9606.ENSP00000311344

    UniGene: Hs.269128