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PSTPIP1 Antibody

  • 货号：
    CSB-PA018944GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O43586
  • 基因名：
  • 别名：
    CD2 antigen binding protein 1 antibody; CD2 binding protein 1 antibody; CD2 cytoplasmic tail binding protein antibody; CD2-binding protein 1 antibody; CD2BP1 antibody; CD2BP1L antibody; CD2BP1S antibody; H PIP antibody; H-PIP antibody; HPIP antibody; PAPAS antibody; PEST phosphatase interacting protein 1 antibody; PEST phosphatase-interacting protein 1 antibody; PPIP1_HUMAN antibody; Proline serine threonine phosphatase interacting protein 1 antibody; Proline-serine-threonine phosphatase-interacting protein 1 antibody; PSTPIP antibody; Pstpip1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PSTPIP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
  • 基因功能参考文献：
    1. We identified HPIP protein expression as a novel independent poor prognostic indicator in cervical cancer PMID: 30033330
    2. Case Report: classical pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome with E250K mutation of PSTPIP1. PMID: 28628471
    3. HPIP expression is associated with high-grade ovarian tumors. PMID: 28039608
    4. we demonstrated that HPIP silencing suppressed TGF-beta1-induced EMT in lung cancer cells by inhibiting Smad2 activation. PMID: 28075456
    5. our study demonstrated that knockdown of HPIP significantly inhibits the proliferation and migration/invasion of HNSCC cells by suppressing the PI3K/Akt signaling pathway. PMID: 27458096
    6. these structural variations in CD2BP1 gene due to the mutations could be one of the strongest reasons to demonstrate the involvement of these gene variations in the patients with rheumatoid arthritis. PMID: 27184502
    7. PSTPIP1 was found to interact with pyrin at the leading edge during cell migration. PMID: 26179737
    8. genetic polymorphism is associated with hyperzincemia and hypercalprotectinemia PMID: 26025129
    9. Molecular interactions between HPIP and FAK, and HPIP and calpain2 regulate cell adhesion and migration through modulation of focal adhesion dynamics. PMID: 25486428
    10. Case Report: missense mutation in PSTPIP1, the gene responsible for PAPA syndrome. PMID: 24960411
    11. we have shown that PSTPIP1 regulates T-cell activation upon CD3 and CD28 stimulation, independently of CD2 costimulation. PSTPIP1 acts downstream of proximal TCR signaling, inhibiting several transcription factors. PMID: 25040622
    12. PSTPIP1 has a role in the pathogenesis of pyoderma gangrenosum through filopodia formation resulting in extracellular matrix degradation PMID: 24421327
    13. novel mutaations found in PSTPIP1 gene in patients with pyoderma gangrenosum PMID: 21790734
    14. non-mutated gene and pyoderma gangrenosum in IBD unresponsive to anakinra treatment PMID: 21438098
    15. The CCTG repeat in the PSTPIP1 promoter may play a role in the pathogenesis of aseptic abscess syndrome and Crohn's disease. PMID: 19731031
    16. CD2BP1-mediated biochemical pathway(s) may function in common inflammatory disorders with apparent etiological overlap, such as rheumatoid arthritis and inflammatory bowel disease PMID: 11971877
    17. PSTPIP1/CD2BP1 protein binds to pyrin PMID: 14595024
    18. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL PMID: 16204241
    19. CD2BP1 directly and negatively impacts T cell activation via isolated CD2 antigen triggering or T-cell receptor stimulation dependent on coordinate CD2 engagement. PMID: 16670297
    20. PSTPIP1 mutants require pyrin to induce formation of ASC pyroptosome, a molecular platform that recruits and activates caspase-1. PMID: 17964261
    21. PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration PMID: 18480402
    22. These findings support the use of monogenic loci as candidates for investigating the genetic component of complex disease and provide preliminary evidence of association between SNPs in autoinflammatory genes and psoriatic JIA. PMID: 18576390
    23. demonstrate that pyrin can recruit PSTPIP1 into aggregations (specks) of ASC, another pyrin binding protein. ASC specks are associated with inflammasome activity PMID: 19584923
    24. PAPA syndrome occurs without identifiable mutation in CD2BB1 PMID: 19700023

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  • 相关疾病：
    PAPA syndrome (PAPAS)
  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, uropodium. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cleavage furrow.
  • 组织特异性：
    Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta.
  • 数据库链接：

    HGNC: 9580

    OMIM: 604416

    KEGG: hsa:9051

    STRING: 9606.ENSP00000452746

    UniGene: Hs.129758