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PTK7 Antibody

  • 货号：
    CSB-PA018996LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA018996LA01HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTK7 Polyclonal antibody
  • Uniprot No.：
    Q13308
  • 基因名：
  • 别名：
    8430404F20Rik antibody; CCK 4 antibody; CCK-4 antibody; Colon carcinoma kinase 4 antibody; Human colon carcinoma kinase 4 (CCK4) mRNA complete cds antibody; Inactive tyrosine-protein kinase 7 antibody; mPTK7/CCK4 antibody; OTTHUMP00000217016 antibody; Protein tyrosine kinase PTK 7 antibody; Protein-tyrosine kinase 7 antibody; Pseudo tyrosine kinase receptor 7 antibody; PTK 7 antibody; PTK7 antibody; PTK7 protein tyrosine kinase 7 antibody; PTK7 protein tyrosine kinase antibody; PTK7_HUMAN antibody; Serum response factor antibody; Srf antibody; Tyrosine-protein kinase-like 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Inactive tyrosine-protein kinase 7 protein (772-1070AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PTK7 Antibody (CSB-PA018996LA01HU)，的标记方式是Non-conjugated。对于PTK7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018996LB01HU PTK7 Antibody, HRP conjugated ELISA
    FITC CSB-PA018996LC01HU PTK7 Antibody, FITC conjugated
    Biotin CSB-PA018996LD01HU PTK7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
  • 基因功能参考文献：
    1. miR2055p is involved in the proliferation, migration and invasion of colorectal cancer cells through inhibiting PTK7. PMID: 29488611
    2. Higher expression of PTK7 significantly indicates worse prognosis in human malignancies PMID: 28924970
    3. Inhibition of PTK7 by siRNA treatment significantly decreases the viability of atypical teratoid rhabdoid tumors (ATRT)patient-derived tumor cell lines.These studies provide the groundwork for future preclinical in vivo studies aiming to investigate the efficacy of PTK7 inhibition on ATRT tumor growth PMID: 28442586
    4. PTK7 localization and protein stability is affected by canonical Wnt ligands. PMID: 28420671
    5. These findings demonstrate that PTK7 upregulates MMP9 through activation of AP-1 and NF-kappaB and, thus increases invasive properties of ESCC cells. PMID: 27689325
    6. PTK7 overexpression is associated with esophageal squamous cell carcinoma. PMID: 28545451
    7. Our data indicate that PTK7 protein expression is associated with the prognosis of oral tongue squamous cell carcinoma PMID: 28547980
    8. PTK7 expression was correlated with tumor differentiation (P=0.027), lymph node metastasis (P=0.005), distant metastasis (P=0.001) and TNM stage (P=0.028) of colorectal cancer patients PMID: 27499181
    9. High PTK7 expression is associated with radioresistance in esophageal squamous cell carcinoma. PMID: 27557627
    10. PTK7 enriches in self-renewing, multipotent stem cells of the human colon. PMID: 26549850
    11. findings implicate PTK7 as a risk factor for NTDs and provide additional evidence for a pathogenic role of PCP signaling in these malformations PMID: 26368655
    12. overexpression in PTK7-negative cancer cells led to increased metastatic events. PTK7 expression thus represents a potential prognostic biomarker and a novel therapeutic target in CRC. PMID: 25962058
    13. data demonstrates that PTK7 regulates the activity of KDR biphasically by inducing oligomerization of KDR molecules at lower concentrations and by surrounding KDR molecules at higher concentrations. PMID: 25986862
    14. PTK7 regulates Id1 expression in CD44-high glioma cell lines. Targeting PTK7 could be an effective strategy for treating glioma with high CD44 expression. PMID: 25204555
    15. The results suggest that N-acylethanolamine acid amidase and protein tyrosine kinase 7 may be used as potential tissue biomarkers to avoid overtreatment of non-aggressive prostate cancer PMID: 24741114
    16. Expression level of PTK7 was significantly decreased from benign to malignant ovarian epithelial tumors. survival analysis showed that patients with negative expression of PTK7 protein had poorer outcome than those with positive expression. PMID: 25550828
    17. PTK7 acts as a cancer-related gene and may be a potent prognostic marker for Hepatocellular carcinoma(HCC). PMID: 25796105
    18. results provide convincing evidence that both PTK7 expression and proteolysis, rather than the level of the cellular full-length PTK7 alone, contribute to efficient directional cell motility and metastasis in cancer PMID: 25006253
    19. PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma (ICC) cells and leads to a poor prognosis in ICC patients. PMID: 24587299
    20. PTK 7 is a transforming gene and prognostic marker for breast cancer and nodal metastasis involvement. PMID: 24409301
    21. This work defines PTK7 as a highly and specifically expressed gene in adenocarcinoma and a potential therapeutic target in this subset of NSCLC. PMID: 24654231
    22. Increased expression of PTK7 was inversely correlated with overall survival. PMID: 23663482
    23. in patients treated by chemotherapy, patients with PTK7-negative tumors seemed to have better DFS than those with PTK7-positive tumors, particularly for patients treated with only anthracycline-therapy drugs PMID: 24023307
    24. PTK7 is a novel marker of epithelial to mesenchymal transitions PMID: 23209741
    25. cleavage of the PTK7 ectodomain by an ADAM proteinase was coupled with the membrane type-1 matrix metalloproteinase (MT1-MMP) cleavage of the PKP(621) downward arrowLI site in the seventh Ig-like domain of PTK7. PMID: 23095747
    26. PTK7 has utility as a biomarker for detecting minimal residual disease of T cell acute lymphoblastic leukemia in the bone marrow PMID: 22898210
    27. a novel role for PTK7 in the tumorigenesis via generation of PTK7-CTF2 by sequential cleavage of ADAM17 and gamma-secretase. PMID: 22665490
    28. aberrations in the membrane type 1 matrix metalloproteinase/PTK7 axis are detrimental to cell movements that shape the body plan PMID: 21518755
    29. Observations may indicate a role for PTK7 in cell proliferation and cell apoptosis and may provide a potential therapeutic pathway for the treatment of a variety of cancers. PMID: 21103379
    30. Protein Tyrosine Kinase 7 is required for beta-catenin-dependent transcriptional events induced by canonical Wnt ligands PMID: 21132015
    31. Results indicate that PTK7 is a major target of MT1-MMP. PMID: 20837484
    32. PTK7 is a planar cell polarity component expressed in the myeloid progenitor compartment that conveys promigratory and antiapoptotic signals into the cell and represents an independent prognosis factor in patients treated with induction chemotherapy. PMID: 20558616
    33. cloning, sequencing and expression of gene and its splice variants PMID: 12427550
    34. Lack of a thermodynamically meaningful self-association propensity for the CCK4 transmembrane domains demonstrates that the conserved GxxxG motif is not sufficient to drive CCK4 transmembrane helix-helix interactions. PMID: 15683231
    35. mechanism of PTK7 upregulation in colorectal cancer PMID: 17671748
    36. PTK7 plays an important role not only in tube formation, migration, and invasion of endothelial cells but also in angiogenesis. PMID: 18471990

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 组织特异性：
    Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
  • 数据库链接：

    HGNC: 9618

    OMIM: 601890

    KEGG: hsa:5754

    STRING: 9606.ENSP00000230419

    UniGene: Hs.90572