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  4. RXFP4 Antibody

RXFP4 Antibody

  • 货号：
    CSB-PA009403
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8TDU9
  • 基因名：
  • 别名：
    RXFP4; GPCR142; GPR100; RLN3R2; Relaxin-3 receptor 2; RLN3 receptor 2; G-protein coupled receptor 100; G-protein coupled receptor GPCR142; Insulin-like peptide INSL5 receptor; Relaxin family peptide receptor 4
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Relaxin Receptor 4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.
  • 基因功能参考文献：
    1. The results confirmed the presence of RXFP4 in human spermatozoa, which localized in the neck and midpiece of sperm. PMID: 28986276
    2. The role of these four INSL5 determinants in distinguishing RXFP4 from RXFP3. PMID: 27404393
    3. analysis of the interaction mechanism of INSL5 with its receptor RXFP4 PMID: 28274616
    4. Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5. PMID: 27888281
    5. The C-terminus of the B-chain of human INSL5 is critical for cognate RXFP4 receptor activity. PMID: 26661035
    6. electrostatic interactions between INSL5 and RXFP4 PMID: 25043977
    7. Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4. PMID: 24802387
    8. relaxin-3/INSL7 is a ligand for GPCR142 [GPCR142] PMID: 14522967
    9. Substitution of the relaxin-3 A-chain with the A-chain from insulin-like peptide 5 results in a chimeric peptide that selectively activates GPCR135 and GPCR142. PMID: 15465925
    10. INSL5 is an endogenous ligand for GPCR142 PMID: 15525639
    11. the N-terminus and EL2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation. PMID: 18582868

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid and colon.
  • 数据库链接：

    HGNC: 14666

    OMIM: 609043

    KEGG: hsa:339403

    STRING: 9606.ENSP00000357301

    UniGene: Hs.449914