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TFB2M Antibody

  • 货号：
    CSB-PA867154LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA867154LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TFB2M Polyclonal antibody
  • Uniprot No.：
    Q9H5Q4
  • 基因名：
    TFB2M
  • 别名：
    N''-adenosyl(rRNA) dimethyltransferase 2 antibody; S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2 antibody; Dimethyladenosine transferase 2 antibody; dimethyladenosine transferase 2 mitochondrial antibody; FLJ22661 antibody; FLJ23182 antibody; h mtTFB antibody; h mtTFB2 antibody; h-mtTFB antibody; h-mtTFB2 antibody; HCV NS5A transactivated protein 5 antibody; HCV NS5A-transactivated protein 5 antibody; hepatitis C virus NS5A transactivated protein 5 antibody; Hepatitis C virus NS5A-transactivated protein 5 antibody; Hkp1 antibody; hTFB2M antibody; Mitochondrial 12S rRNA dimethylase 2 antibody; mitochondrial antibody; Mitochondrial dimethyladenosine transferase 2 antibody; Mitochondrial transcription factor B2 antibody; mtTFB antibody; mtTFB2 antibody; NS5ATP5 antibody; S-adenosylmethionine-6-N'' antibody; TFB2M antibody; TFB2M_HUMAN antibody; Transcription Factor B2 antibody; Transcription factor B2 mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TFB2M Antibody (CSB-PA867154LA01HU)，的标记方式是Non-conjugated。对于TFB2M Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA867154LB01HU TFB2M Antibody, HRP conjugated ELISA
    FITC CSB-PA867154LC01HU TFB2M Antibody, FITC conjugated
    Biotin CSB-PA867154LD01HU TFB2M Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity.
  • 基因功能参考文献：
    1. Study reports crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mitochondrial RNA polymerase to achieve promoter-dependent initiation. PMID: 29149603
    2. demonstrate that a complex composed of TFAM and POLRMT was readily formed at the promoter but alone was insufficient for promoter melting, which only occurred when TFB2M joined the complex PMID: 28028173
    3. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. PMID: 24413562
    4. only two essential initiation factors, TFAM and TFB2M, and two promoters, LSP and HSP1, are required to drive transcription of the mitochondrial genome PMID: 20410300
    5. The mRNA levels of TFB1M and TFB2M are influenced by endurance training PMID: 19681768
    6. This transcription factor activates transcription of human mitochondrial DNA. PMID: 12068295
    7. Distinct, but possibly coordinated functions of mtTFB1 and mtTFB2 in mitochondrial gene expression and biogenesis. PMID: 17557812
    8. This study suggested that DNA variants in TFB2M did not contribute to the risk for parkinson disease. PMID: 18980857
    9. determined the variation in the TFAM, TFB1M, and TFB2M genes in cardiac hypertrophy PMID: 19096125
    10. rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M, but not TFB2M. PMID: 19417006
    11. Promoter-independent DNA conformation-dependent transcription required TFB2M. PMID: 19624753

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family, KsgA subfamily
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 18559

    OMIM: 607055

    KEGG: hsa:64216

    STRING: 9606.ENSP00000355471

    UniGene: Hs.7395