Recombinant Human Sodium-dependent serotonin transporter (SLC6A4), partial

1. platelet 5-HT content and SERT as peripheral surrogates in depression and anxiety patients PMID: 30031795
2. The relationship between bullying and pain was modified by genetic variation in the promotor region of SLC6A4. Study data indicated that the effect of bullying on health and well-being is dependent on a gene-environment interaction. PMID: 29313869
3. This study showed an interaction exists in which the S allele of 5-HTTLPR increases risk of depression only in stressed individuals. PMID: 28373689
4. STin2 VNTR polymorphism of SLC6A4 gene may contribute to Crohn's disease pathogenesis. PMID: 30394015
5. 5HTTLPR and dating violence victimization interact to increase odds of marijuana use. PMID: 30049530
6. ECs derived miR-195 acts as a new regulator to modulate the expression of 5-HTT in SMCs. PMID: 28272473
7. rs591323 had the effect on SERT availability of pons in healthy male subjects, not in female subjects. SERT availability of AA genotype of rs591323 was lower than those of the other 2 genotypes. However, SNPs of risk loci for Parkinson's disease did not show any effect on DAT availability. PMID: 29774458
8. platelet BDNF and SERT do not specifically underlie psychosocial deficits in stage Huntington's Disease PMID: 30039833
9. SLC6A4 l/l carriers have a better ability to perceive and focus their attention on the elements of their environment and to have the capacity to understand and predict what will happen with those elements. PMID: 29298559
10. 5-HTTLPR's variant moderates Adolescent Substance Misuse Initiation. PMID: 27861757
11. High serotonin and SERT levels may indicate that these biomarkers have a role in the autism pathogenesis and support the possibility of using serotonin and SERT to diagnose autism severity PMID: 29738009
12. Findings indicated that the SERT insertion/deletion polymorphism may serve as a genetic biomarker of irritable bowel syndrome in Asians and Caucasians. [meta-analysis] PMID: 30121382
13. results showing strong associations of childhood neglect and abuse and significant effects of the low-expressing alleles (S; L G ) of 5-HTTLPR with alexithymia. PMID: 29306941
14. Alcohol use may be positively related, at least cross-sectionally, to depressive symptoms in female carriers of the 5-HTTLPR S allele, and indicate that moderators such as SLC6A4 genotype and sex need to be taken into account when examining associations between depressive symptoms and drinking behavior. PMID: 29220746
15. The SERT gene promoter SNP rs25531 was associated with the cancer-related fatigue in patients with colon and rectal cancer PMID: 29551185
16. No differences were found between murderers and thieves either concerning 5HTTLPR and 5-HT2C genotypes or concerning psychological measures. Comparison of polymorphism distribution between groups of prisoners and controls revealed highly significant associations of 5HTTLPR and 5-HTR2C (rs6318) gene polymorphisms with being convicted for criminal behavior. PMID: 29621775
17. Significant association was observed between the S/S genotype of the SLC6A4 polymorphism and globus pharyngeus, suggesting that SLC6A4 is a potential candidate gene involved in the pathogenesis of globus pharyngeus. PMID: 29310115
18. Association of SLC6A4 variants with familial form of OCD. PMID: 28691545
19. 5-HTTLPR genotype was associated with traffic behaviour: The S'-allele carriers had significantly lower odds for speeding offences and traffic accidents. The lower prevalence of S'-allele carriers among those who had committed speeding offences was statistically significant in females, while the lower prevalence of having been involved in a traffic accident was rather observed in males. PMID: 29407665
20. In the present study we systematically investigated the contribution of SNPs toward Social anxiety disorder by performing genotyping of 24 SNPs that have been reported previously in SAD or other psychiatric disorders. This showed an association between rs140701 at SLC6A4 and SAD, especially in Social anxiety disorder patients without panic disorder. PMID: 28272115
21. Functional network-based phenotype links genetic variation in 5-HTTLPR to emotion regulation. PMID: 28589968
22. These findings indicate that TPH1, TPH2, and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants. PMID: 28590957
23. This study found that the SLC6A4 hyper-methylation and hypo-expression was found in healthy subjects with childhood trauma. PMID: 29056292
24. resilience fully mediated the association between the S 5-HTTLPR allele and depression in the medically ill. PMID: 28903099
25. Study applied graph theory analysis on resting-state fMRI of 120 women selected based on neuroticism score, & genotyped 2 polymorphisms: 5-HTTLPR (S-carriers and L-homozygotes) and COMT (rs4680-rs165599; COMT risk group and COMT non-risk group). For the 5-HTTLPR polymorphism, found that subnetworks related to cognitive control show less connections with other subnetworks in S-carriers compared to L-homozygotes. PMID: 27743374
26. The nursing diagnoses of risk for suicide and imbalanced nutrition are reported less often in 5-HTTLPR homozygotes of the high-expressing gene (LA). Carriers of the low-expressing genes (LG or S) have a worse response to interventions which aim to increase low self-esteem, indicating that they may need more intensive care in order to achieve the desired outcome. PMID: 29016262
27. Pilot study demonstrated an increase in the SLC6A4 promoter DNA methylation levels in the saliva of children and adolescents with obsessive-compulsive disorder. DNA methylation provides one important epigenetic mechanism through which environmental influences can affect psychiatric disease risk. PMID: 29102815
28. genetic association studies in population in Spain: Data suggest genetic polymorphisms in SLC6A4 promoter region are associated with ability to control food intake in overweight/obese subjects while in weight loss programs; SLC6A4 promoter polymorphisms interact with emotional eating to modulate weight loss. The biggest challenge for losing weight is the ability to control the amount of food eaten. PMID: 28766852
29. findings suggest that the 5-HTTLPR S allele is associated with lower BMD in adults younger than 50 years PMID: 28892067
30. Depression remitted 5-HTTLPR S/Lg-carriers who experienced childhood trauma automatically avoided sad facial expressions relatively more than LaLa homozygotes with childhood trauma. Remitted LaLa-carriers who had not experienced childhood trauma, avoided sad faces relatively more than LaLa homozygotes with childhood trauma. Study did not find a main effect of childhood trauma. PMID: 29547643
31. In a study of the genetic association between polymorphisms in the DAT1, SERT, COMT and BDNF genes and attention deficit and hyperactive disorder, transmission disequilibrium test analysis showed that no individual allele of any variant studied has a preferential transmission PMID: 29122229
32. Participants who assessed themselves with greater interdependence reported lower death anxiety/depression and showed decreased neural response to death-related words in emotion-related brain regions including the anterior cingulate, putamen, and thalamus. However, these results were evident in long/long allele carriers of the 5-HTTLPR but not in short/short allele carriers. PMID: 28921740
33. 5-HTTLPR S-allele carriers showed a more negative relation between stress exposure and connectivity of the executive control network than L-allele homozygotes, specifically in the pre/postcentral gyrus, striatum, and frontal pole. In the default mode network, found a positive association between the GxE and supramarginal gyrus connectivity. PMID: 27738993
34. Study found a significant interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Mean connectivity in the right inferior parietal lobule was positively correlated with working memory performance. PMID: 28793232
35. SIDS is associated with peripheral abnormalities in the 5-HT pathway: compared with postmortem infant SIDS and postmortem infant control samples, living infant controls had higher concentrations of serum 5-HT and lower concentrations of 5-HIAA PMID: 28674018
36. Findings support the relevance of peripheral SLC6A4 promoter DNA methylation for frontal-limbic brain processes in healthy individuals, and provided some support for convergence across blood, saliva and epithelial tissues. Buccal epithelial cells may be most sensitive surrogate samples in DNA methylation studies to detect frontal-limbic brain associations. PMID: 28774705
37. The 5-HTTLPR polymorphism was associated with the rate of achievement of remission and tolerability of treatment: carriers of the SS genotype achieved remission less frequently and more frequently experienced side-effects. PMID: 27029447
38. A significant 5-HTTLPRxearly adversity interaction indicated that greater early adversity was associated with lower latent trait cortisol levels, but only among individuals with either L/L or S/L genotype. Findings suggest that serotonergic genetic variation may influence the impact of early adversity on individual differences in hypothalamic-pituitary-adrenal axis regulation. PMID: 28757071
39. 5-HTTLPR and childhood adversity are associated with the personality trait openness to experience. PMID: 28800511
40. These data suggest that the carriage of the short form of the 5-HTTLPR may negate the protective effect of psychological resilience against in patient wit depression. PMID: 28774788
41. Study shows that individuals homozygous for the long allele of the 5-HTTLPR gene respond to stressful events by reappraising their emotional meaning, which may hamper the harmful effect of stress on mental health. PMID: 28901577
42. The 5-HTTLPR polymorphism was associated with neuroticism in women with Premenstrual Dysphoric Disorder. There is more evidence for a role of SERT polymorphisms in Postpartum Depression. PMID: 29082433
43. Study suggests that epigenetic mechanisms rather than 5-HTTLPR alone influence in vivo human serotonin transporter (5-HTT) availability. PMID: 28675387
44. SERT binding in the diencephalon is reduced in insulin-resistant subjects independently of body weight, while hypothalamic SERT binding tends to be lower in obesity, with no difference between insulin-resistant and insulin-sensitive subjects. This suggests that the metabolic perturbations associated with obesity independently affect SERT binding within the diencephalon. PMID: 27626923
45. The current meta-analysis provides new evidence for the robustness of the interaction between stress and 5-HTTLPR in depression. PMID: 29031184
46. Serotonin transporter (5-HTT) is responsible for removing serotonin from the synaptic cleft, returning it to the presynaptic neuron, thereby determining the extent, duration and spatial domain of the serotonergic activation. PMID: 26860734
47. Study found that S-carriers, relative to LL-homozygous individuals, showed increased magnetoencephalography gamma band power within the amygdala for the late amygdala response to fearful expressions (i.e., after information had been processed within superior temporal sulcus) and not for the early response. PMID: 28580622
48. It is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer. PMID: 28590587
49. Studied association of aggression and 5-HTTLPR, 5HTR1A, and 5HTR2A genetic polymorphisms in industrial Russian and traditional Tanzanian population groups. PMID: 29661255
50. the allelic distribution of solute carrier family-6 member-4 promoter region in Turkish athletes, is reported. PMID: 28719342

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HGNC: 11050

OMIM: 103780

KEGG: hsa:6532

STRING: 9606.ENSP00000261707

UniGene: Hs.134662