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  4. Recombinant Human herpesvirus 2 Envelope glycoprotein B (gB),Partial

Recombinant Human herpesvirus 2 Envelope glycoprotein B (gB),Partial

In Stock
  • 货号：
    CSB-EP362479HJX
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    gB
  • Uniprot No.：
  • 别名：
    gB; UL27; Envelope glycoprotein B; gB
  • 种属：
    Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    44.4kDa
  • 表达区域：
    23-279aa
  • 氨基酸序列
    APAAPAAPRASGGVAATVAANGGPASRPPPVPSPATTKARKRKTKKPPKRPEATPPPDANATVAAGHATLRAHLREIKVENADAQFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINTKGVCRSTAKYVRNNMETTAFHRDDHETDMELKPAKVATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    Like all recombinant proteins, this Recombinant HHV-2 gB protein was encoded by recombinant DNA. The recombinant DNA was introduced to a plasmid in which the gene of gB was cloned downstream of a promoter region. When the plasmid was introduced to the cells of E.coli, the E.coli’s own protein synthesis pathways would then result in the expression of the gB protein. And the next step was protein purification. The purity of this recombinant protein is 90%+ determined by SDS-PAGE.

    Herpesvirus 2 Envelope glycoprotein B (gB) is also called UL27. The human cytomegalovirus nuclear UL27 protein could be involved at the stage of nuclear egress. Maribavir is a new anti-HCMV drug that targets nuclear egress through direct inhibition of the HCMV serine-threonine kinase, UL97 protein. Because maribavir-resistance-related mutations are observed in both proteins, UL27 is thought to interfere with UL97 activity. UL27 might either directly or indirectly involved in the mechanism of action of maribavir. Furthermore, MBV-resistant mutations also emerged in the UL27 gene in vitro and could compensate for the inhibition of pUL97 kinase activity. Sodium tanshinone IIA sulfonate affects Marek's disease virus replication by inhibiting gB expression.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
  • 亚细胞定位：
    Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Herpesviridae glycoprotein B family