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  4. Recombinant Mouse Leukemia inhibitory factor receptor (Lifr), partial

Recombinant Mouse Leukemia inhibitory factor receptor (Lifr), partial

  • 货号：
    CSB-YP012929MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP012929MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP012929MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP012929MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP012929MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Lifr; Leukemia inhibitory factor receptor; LIF receptor; LIF-R; D-factor/LIF receptor; CD antigen CD118
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
  • 基因功能参考文献：
    1. s demonstrate heterozygous novel or rare LIFR mutations in 3.3% of CAKUT patients, and provide evidence that Lifr deficiency and deactivating LIFR mutations cause highly similar anomalies of the urogenital tract in mice and humans. PMID: 28334964
    2. uterine expression of the LIFR is essential for embryo implantation; this further define the components of the LIF signaling pathway necessary for effective implantation. PMID: 28368537
    3. OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR. PMID: 27539849
    4. The predominant role of leukemia inhibitory factor receptor in skeletal muscle regeneration appears to be in regulating the inflammatory response rather than directly effecting myogenic cells. PMID: 22926285
    5. Data confirmed that LIF and the LIFR were up-regulated in intra-implantation sites compared to inter-implantation sites on Day 5 of gestation. PMID: 21966484
    6. Neuropoietin induced activation of STAT3 tyrosine phosphorylation in adipocytes is independent of LIFR phosphorylation and degradation. PMID: 20353755
    7. Review. The structure and function of the LIF-R gene and protein and the role of its cytoplasmic domain in myeloid leukemia cells are reviewed. PMID: 11042511
    8. directly prevents oligodendrocyte death in animal models of multiple sclerosis PMID: 12042813
    9. LIFR plays a role in modulating fetal response to high maternal glucocorticoids in late gestation, likely mediated through the glucocorticoid receptor, with implications for adult homeostasis as a direct tie between immune, neural & hormone function. PMID: 12823859
    10. LIFR signaling can exert negative regulatory effects on neurite extension and branching of sympathetic neurons PMID: 12871977
    11. Although not necessary for neural stem cell self-renewal, LIFR activation enhances both the clonogenicity and expression of glial fibrillary acid protein (GFAP) by these multipotential cells. PMID: 15519241
    12. Lifr -/- mice demonstrate elevated pituitary glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA and protein levels, indicating the importance of LIF signaling for hypothalamic-pituitary adrenal axis development. PMID: 16081071
    13. Data show that demyelination induces oligodendrocyte expression of SOCS3, that this induction depends on leukemia inhibitory factor (LIF) and LIF receptors, and that endogenous LIF may be a key determinant of the CNS response to oligodendrocyte loss. PMID: 16682639
    14. provides a structural template to understand the formation and orientation of the high-affinity signaling complex between LIF, LIF receptor, and gp130 PMID: 17652170
    15. From the analysis of lifr beta mutant embryos, it was established that LIFR beta is necessary for fbm neurons' identity determination and is implicated in astrocyte and oligodendrocyte differentiation, specifically within the facial nucleus. PMID: 18031722
    16. Endogenous LIF is an immunologically active molecule in neuroinflammation. PMID: 18250427
    17. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. PMID: 19344761

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 组织特异性：
    Placenta, liver, kidney, heart, lung, brain, and embryos. The liver may be the primary site of synthesis of the secreted form.
  • 数据库链接：

    KEGG: mmu:16880

    STRING: 10090.ENSMUSP00000064551

    UniGene: Mm.149720