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  4. Recombinant Mouse Noggin (Nog)

Recombinant Mouse Noggin (Nog)

  • 货号：
    CSB-YP015917MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015917MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015917MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015917MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015917MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    NogNoggin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-232
  • 氨基酸序列
    QHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6.
  • 基因功能参考文献：
    1. Noggin null mice display cutaneous syndactyly and impaired interdigital mesenchyme specification. Failure of webbing regression was caused by lack of cell cycle exit and interdigital apoptosis. Noggin null mutants have increased Indian hedgehog (Ihh) expression in cartilage condensations leading to aberrant extension of IHH downstream signaling into the interdigital mesenchyme. PMID: 29771958
    2. Down-regulation of Noggin and miR-138 cooperatively promoted osteogenic differentiation of mesenchymal stem cells. PMID: 29094227
    3. the absence of Noggin, and consequently BMP hypersignaling, leads to the decrease of the number of muscle progenitor cells and their phenotypic shift towards adipocytes in vitro. PMID: 27573479
    4. Bone morphogenetic protein signaling and its antagonism by NOGGIN play a role in osteoarthritis development. PMID: 27769098
    5. We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist. PMID: 27144312
    6. we observed a glial reaction and an activity-dependent modification of Shh, Noggin, and Numb proteins. we found that Shh and Noggin could affect motor performance and that these proteins could be associated with both TDP-43 and Numb PMID: 26064939
    7. Molecular analysis demonstrated that ectopic Noggin-expressing regions in the early heart's pacemaker region, failed to express the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 PMID: 25428115
    8. endogenous Bmp2, Bmp4, and Noggin transcript levels in postnatal bone and cartilage mirrored the activity of their respective reporters in these tissues PMID: 25043193
    9. A band of noggin-expressing cells insulates a region of proliferative chondrocytes from the influence of BMP signaling, allowing them to differentiate as articular cartilage upon exposure to Wnt signaling emanating from the interzone. PMID: 25758226
    10. Taken together, these results show that hair follicle development in Trps1 KO embryos is impaired directly or indirectly by decreased Noggin expression. PMID: 25514040
    11. BMP signaling was stimulated in adipose derived stem cells (ASCs) by downregulating noggin. PMID: 23977305
    12. The axial midline domain of Nog expression is critical to promote pharyngeal arch 1 development in early stages, necessary for adequate outgrowth of the mandibular bud. PMID: 24949938
    13. Follistatin aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin-deficient state. PMID: 24514266
    14. Noggin antagonizes BMP, which is required in presumptive notochord cells for mammalian foregut morphogenesis PMID: 24631216
    15. Noggin is expressed constantly in Meckel's cartilage (MC) and in the absence of Noggin, MC is significantly thickened attributing to dramatically elevated cell proliferation rate associated with enhanced phosphorylation of Smad1/5/8. PMID: 23891934
    16. MiR-200c represses noggin in dental epithelial-like cells. PMID: 23863486
    17. Noggin stimulates myogenesis from dorsal aorta progenitors. PMID: 22370001
    18. Bone morphogenetic proteins and noggin have different roles in the processes of glial scar formation and neurorestoration in the ischemic brain. PMID: 22297545
    19. Noggin inactivation causes osteopenia, suggesting that BMP in excess have a detrimental effect on bone or that noggin has a BMP-independent role in skeletal homeostasis. PMID: 22334719
    20. a novel mechanism by which noggin directly induces adipogenesis of mesenchymal stem cells independently of major adipogenic signals. PMID: 22351751
    21. Noggin is initially expressed in maxillary mesenchyme next to upper incisor at initiation stage, then in developing teeth. mutants form single medial upper incisor arrested at late bud stage. observations show importance of BMP signaling homeostasis. PMID: 22302143
    22. Increased Bmp signaling in Noggin(-/-) mice results in downregulation of the hedgehog pathway at a critical stage when the midline craniofacial structures are developing, which leads to a phenotype consistent with a microform of HPE. PMID: 21821669
    23. Nog and Grem1 cooperate to maintain a BMP signaling-free zone that is a crucial prerequisite for Hh-mediated sclerotome induction. PMID: 21303853
    24. Noggin mediated modulation of BMP signaling is essential for palatal epithelium integrity and for normal palate development. PMID: 20727875
    25. Noggin-transduced cells produced more photoreceptor cells than non-transduced cells, suggesting that noggin has the ability to induce human bone-marrow-derived mesenchymal stem cells to trans-differentiate into photoreceptor cells. PMID: 20795361
    26. regulates hair cell numbers in organ of corti PMID: 20063299
    27. control of Noggin by Sox9 may be a potent regulatory mechanism in chondrocyte differentiation PMID: 11869287
    28. role in promoting lineage commitment in embryonic stem cells PMID: 11969257
    29. Noggin has a role in mouse metanephric development PMID: 12141440
    30. the BMP antagonists chordin and noggin promote the inductive and trophic activities of rostral organizing centers in early development of the mammalian head PMID: 12397106
    31. Noggin is required for correct guidance of dorsal root ganglion axons. PMID: 12435358
    32. Noggin arrests the differentiation of bone marrow stromal cells, preventing cellular maturation. PMID: 12633782
    33. stage specific effects on osteoblastic differentiation: prevents differentiation at the preosteoblastic level PMID: 12647299
    34. Syndromic craniosynostoses may be the result of inappropriate downregulation of BMP antagonist noggin expression PMID: 12687003
    35. Transgenic mice overexpressing noggin in the bone microenvironment have decreased trabecular bone volume and impaired osteoblastic function, leading to osteopenia and fractures. PMID: 12697704
    36. Recombinant Shh protein upregulates this mesodermal biological marker. PMID: 12781691
    37. Data show that eyelid opening is strongly inhibited in transgenic mice overexpressing the bone morphogenetic protein antagonist noggin from the keratin 5 promoter in the epidermis. PMID: 12805214
    38. Dkk1 and noggin functionally cooperate in the head organizer. PMID: 12952897
    39. Results suggest that noggin, expressed in mature osteoblasts, inhibits osteoblast differentiation and bone formation. PMID: 12975477
    40. BMPR-1A, -2, and Noggin are upregulated in undifferentiated mesenchymal cells and regenerating muscle fibers occurs during the early phase of BMP-2-induced bone formation PMID: 14584896
    41. role of target-derived BMP signaling in development of sensory ganglia and the sensory innervation of the skin was examined in transgenic animals that overexpress either the BMP inhibitor noggin or BMP4 PMID: 14973275
    42. noggin and sclerostin form a mutually inhibitory complex that fine-tunes of BMP activity in bone homeostasis PMID: 15199066
    43. noggin expression is repressed by FGF18 PMID: 15252029
    44. opposite effects of Noggin and bFGF for the neural tube development PMID: 15703886
    45. The reduction of Bmp4 dosage results in an extensive rescue of the axial skeleton of Noggin mutant embryos. PMID: 16122729
    46. Noggin was expressed in bone marrow cells in the vertebrae, chondrocytes and hyaline cartilage cells and fibrous cells in the intervertebral discs PMID: 16503488
    47. Noggin expression during the early stages of thymus and parathyroid organogenesis. PMID: 16517216
    48. All Noggin-/- pups are born with lumbar spina bifida; elevated BMP4 signaling in the mesoderm between the limb buds leads to abnormal somite differentiation and axial skeletal malformation PMID: 16712836
    49. Overexpression of noggin in bone revealed that BMP signals regulate bone development through stimulation of osteoblasts and osteoclasts. PMID: 16813523
    50. Both increased epithelial-to-mesenchymal transformation and atrioventricular outflow tract (OFT) colonization underlie the enlarged OFT cushion phenotype of Noggin knockout mutants. PMID: 17218603

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Noggin family
  • 组织特异性：
    Expressed in condensing cartilage and immature chondrocytes.
  • 数据库链接：

    KEGG: mmu:18121

    STRING: 10090.ENSMUSP00000061427

    UniGene: Mm.135266