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  4. Recombinant Mouse P2X purinoceptor 1 (P2rx1), partial

Recombinant Mouse P2X purinoceptor 1 (P2rx1), partial

  • 货号：
    CSB-YP017319MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017319MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017319MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017319MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017319MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    P2rx1; P2X purinoceptor 1; P2X1; ATP receptor; Purinergic receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.
  • 基因功能参考文献：
    1. s proposed a tentative intracellular signaling pathway of the acetylcholine-induced ciliary beat, in which the pannexin-1-purinergic P2X receptor unit may play a central role in ciliary beat regulation PMID: 29676177
    2. Quite the reverse is seen in P2X1(-/-) mice, which had markedly lower cytokine levels and less coagulation activation compared to controls after exposure to uropathogenic Escherichia coli. PMID: 28428949
    3. secretion of IL-22 in the regenerating liver is modulated by the ATP receptor, P2X1 PMID: 26853442
    4. Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism. PMID: 25921923
    5. This study reveals a major role for the P2X1 receptor in LPS-induced lethal endotoxemia through its critical involvement in neutrophil emigration from venules. PMID: 25480563
    6. NTPDase1 controls male fertility via the regulation of P2X1 activation. PMID: 25160621
    7. The presence of the P2X1 receptor on both polymorphonuclear neutrophils and platelets is important for fibrin generation and thrombus formation in vivo. PMID: 25150292
    8. Male contraception via simultaneous knockout of alpha1A-adrenoceptors and P2X1-purinoceptors in mice. PMID: 24297884
    9. P2X(1) ion channels play a protective role in endotoxemia by negatively regulating systemic neutrophil activation, thereby limiting the oxidative response, coagulation, and organ damage. PMID: 22212928
    10. loss of Dicer may impair the expression of miRNAs that are capable of targeting P2x mRNAs. PMID: 22796409
    11. The activity of P2X2/3 receptors in nodose ganglion neurons is involved in the transmission of myocardial ischemic nociceptive signal. PMID: 20615761
    12. The P2X receptor phenotype in megakaryocytes and (by inference) platelets is due to expression of homomeric P2X1 receptors. PMID: 11815371
    13. P2X(1) receptor-deficient mice establish the native P2X receptor and a P2Y6-like receptor in arteries. PMID: 12435812
    14. Data suggest that the P2X1 receptor contributes to the formation of platelet thrombi, particularly in arteries in which shear forces are high. PMID: 12913094
    15. P2X1 receptors have a role in renal microvascular autoregulatory behavior PMID: 14679185
    16. altered function of P2X receptors may be an important contributor to pathogenic Ca2+ entry in dystrophic mouse muscle and may have implications for the pathogenesis of muscular dystrophies PMID: 16581969
    17. analysis of a novel interaction between platelet P2X1 and thrombin receptors, with P2X1 functioning to amplify aggregation responses at low levels of thrombin receptor stimulation PMID: 16634759
    18. The data support the hypothesis that jCaTs represent Ca(2+) that enters smooth muscle cells through P2X(1) receptors activated by neurally released ATP and this Ca(2+) is involved in the initial rapid component of the sympathetic neurogenic contraction. PMID: 16920810
    19. The absence of a correlation between DE and neuroeffector calcium transient amplitudes suggests that the NCT amplitude is a poor measure of quantal size. PMID: 17629625
    20. Thus an increased SR Ca(2+) content, occurring in the absence of cAMP accumulation or L-type Ca(2+) channel activation, is the principal mechanism by which cardiac P2X receptor mediates a stimulatory effect on cardiac myocyte contractility. PMID: 17873021
    21. Mouse peritoneal macrophages that are minimally activated demonstrate membrane currents in response to ATP and alpha beta meATP that have the predominate features of P2X1 receptors PMID: 17934511
    22. analysis of ectodomain lysines and suramin block of P2X1 receptors PMID: 18765669
    23. Activation of P2X1 ion channels by adenosine triphosphate (ATP) promotes neutrophil chemotaxis via Rho kinase-dependent actomyosin-mediated contraction at the cell rear. PMID: 19635923

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    P2X receptor family
  • 数据库链接：

    KEGG: mmu:18436

    STRING: 10090.ENSMUSP00000021141

    UniGene: Mm.25722