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  4. Recombinant Xenopus laevis Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A (jmjd6-a)

Recombinant Xenopus laevis Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A (jmjd6-a)

  • 货号：
    CSB-YP743437XBE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP743437XBE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP743437XBE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP743437XBE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP743437XBE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    jmjd6-a
  • Uniprot No.：
  • 别名：
    jmjd6-a; ptdsr-a; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A; EC 1.14.11.-; Histone arginine demethylase JMJD6-A; JmjC domain-containing protein 6-A; Jumonji domain-containing protein 6-A; Lysyl-hydroxylase JMJD6-A; Peptide-lysine 5-dioxygenase JMJD6-A; Phosphatidylserine receptor-A; Protein PTDSR-A
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-403
  • 氨基酸序列
    MNHKSKKRIK EAKRSARPEL KDSQDWCRHN YCEVFSLNPS TVRDNVERAD DAHLSIEEFI DRYEKPYKPV VIVNATADWP AQEKWTLERL KRKYRNQKFK CGEDNDGYSV KMKMKYYIDY MEGTRDDSPL YIFDSSYGEH PKRKKLLEDY EVPKYFRDDL FQFAGEKRRP PYRWFVMGPA RSGTGIHIDP LGTSAWNSLV HGHKRWCLFP TNTPRELIKV TRDEGGNQQD EAITWFNVIY PRTQLPSWPP EFKPLEILQK PGETVFVPGG WWHVVLNLDT AIAVTQNFAS CSNFPVVWHK TVRGRPKLSR KWYRILKQER PELAALADTV DLQEATGIAS DSSSDSSSSS SSSSSESCSE DDLSSGAEMM SHRKKKRKIC SVMENGDSTT QDDCVSKERS SSR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with brd4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. Demethylates other arginine methylated-proteins such as esr1. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation.
  • 亚细胞定位：
    Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    JMJD6 family
  • 数据库链接：

    KEGG: xla:444377

    UniGene: Xl.16707