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  4. CHOK1/Mouse CCR8 Stable Cell Line

CHOK1/Mouse CCR8 Stable Cell Line

  • 货号：
    CSB-SC004847MO
  • 规格：
    1 vial contains approximately 5x106 cells in 1 ml
  • 价格：
    ￥30000
  • 活性：
    • Untransfected CHO-K1 cells (green line) and transfected Mouse CCR8 CHO-K1 Stable cells (red line) were stained with anti-Mouse CD198-PE antibody (2µg/1*106cells) and analyzed with flow cytometry.
  • 其他：

产品详情

  • Uniprot No.：
    P56484
  • 生长类型：
    Adherent
  • 抗性：
    Puromycin
  • 培养基：
    F-12K + 10% FBS + 6μg/mL Puromycin
  • 别名：
    CCR8
  • 蛋白标签：
    Tag-Free
  • 保存缓冲液：
    35% FBS + 55% F-12K + 10% DMSO
  • 应用范围：
    Binding assay by FACS and cell based ELISA.
  • 储存条件：
    Frozen in liquid nitrogen or stored at -80°C
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

靶点详情

  • 功能：
    Receptor for the CCL1/SCY1/TCA-3 chemokine.
  • 基因功能参考文献：
    1. CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin. PMID: 25344933
    2. Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. PMID: 24714157
    3. A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c(+) Aantigen presenting cells. PMID: 23798714
    4. Expression of CCR-8 in microglia was upregulated in the presence of CCL-1. PMID: 23747724
    5. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
    6. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. PMID: 22031018
    7. a key regulator of Th2 cell skin recruitment during IL-5-mediated allergic inflammation PMID: 21217759
    8. mediates increased responsiveness of murine eosinophils to TCA-3 PMID: 12050188
    9. Data from three different models plus an in vivo blocking study clearly show that the Th2 cell-mediated pathological response to ovalbumin-induced allergic airway inflammation is not critically CCR8-dependent. PMID: 12574386
    10. sulfation at specific positions of the N-terminal domain of mouse CCR8 is critical for its biological activity, whereas glycosylation has a minor influence PMID: 14736884
    11. IL-10 production correlates with CCR8 ligand (CCL1) expression and the appearance of CCR8+ cells in granulomatous lungs and is required for full expression of the T helper type 2 cell response to parasite antigens. PMID: 15699124
    12. CCR8 may have a negative impact on host defense during septic peritonitis, providing a new paradigm for the role of CCR8 in innate immunity. PMID: 16384913
    13. CCR8 ligands are allotropic, binding to distinct sites within CCR8 PMID: 17023422
    14. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
    15. Ccr8 has a pivotal role in the progression of experimental fungal asthma. PMID: 17321573
    16. Mast cell-derived CCR8- and CCL1-expressing CD4-positive effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses. PMID: 17641040
    17. Results suggest that CCR8 plays a significant role in the pathogenesis of experimental autoimmune encephalomyelitis and probalby of multiple sclerosis. PMID: 17850582
    18. CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation PMID: 17947648

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in thymus.
  • 数据库链接：

    KEGG: mmu:12776

    STRING: 10090.ENSMUSP00000038473

    UniGene: Mm.442098