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  4. Recombinant Human SARS coronavirus Membrane protein (M)

Recombinant Human SARS coronavirus Membrane protein (M)

  • 货号：
    CSB-CF348664HQE
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    M
  • Uniprot No.：
  • 别名：
    M; 5; Membrane protein; M protein; E1 glycoprotein; Matrix glycoprotein; Membrane glycoprotein
  • 种属：
    Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-221
  • 氨基酸序列
    MADNGTITVEELKQLLEQWNLVIGFLFLAWIMLLQFAYSNRNRFLYIIKLVFLWLLWPVT LACFVLAAVYRINWVTGGIAIAMACIVGLMWLSYFVASFRLFARTRSMWSFNPETNILLN VPLRGTIVTRPLMESELVIGAVIIRGHLRMAGHSLGRCDIKDLPKEITVATSRTLSYYKL GASQRVGTDSGFAAYNRYRIGNYKLNTDHAGSNDNIALLVQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
  • 基因功能参考文献：
    1. Specific amino acids are critical for M protein function in terms of directing virus assembly. PMID: 23700447
    2. Like S, M acquires high-mannose N-glycans that are subsequently modified into complex N-glycans in the Golgi. PMID: 15831954
    3. This is the first report describing the induction of apoptosis by SARS-CoV M protein in animal cells and possible implications are discussed. PMID: 16797548
    4. The results show that M and N proteins of SARS-CoV can induce apoptosis of human pulmonary fibroblast cells. PMID: 16845612
    5. The crystal structure of M(pro) at a resolution of 1.82 Angstroms, in space group P2(1) at pH 6.0, is reported. PMID: 17196984
    6. cytoplasmic C-terminus domain of SARS-CoV M protein was responsible for binding to NC protein PMID: 18792806
    7. the expression of M protein prevents the formation of TRAF3.TANK.TBK1/IKKepsilon complex and thereby inhibits TBK1/IKKepsilon-dependent activation of IRF3/IRF7 transcription factors PMID: 19380580

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  • 亚细胞定位：
    Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Betacoronaviruses M protein family
  • 数据库链接：

    KEGG: vg:1489672