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  4. Recombinant Rat Bcl-2-like protein 1 (Bcl2l1)

Recombinant Rat Bcl-2-like protein 1 (Bcl2l1)

  • 货号：
    CSB-CF002613RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Bcl2l1; Bclx; Blc2l; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-233
  • 氨基酸序列
    MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEPERETPSAINGNPSWHLA DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEP WIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.; Isoform Bcl-X(S) promotes apoptosis.
  • 基因功能参考文献：
    1. evidence that impaired expression of CK2 results in destabilization of the Bcl-2 mammalian homolog Bcl-xL, which is known to stabilize the mitochondrial membrane potential, through a mechanism involving disruption of the chaperone function of heat shock protein 90. PMID: 28597245
    2. our results showed that the expression of platelet-derived miR-142-3p and the apoptosis were both significantly increased in ECs during hypertension. The present results suggested that platelet-derived miR-142-3p is delivered into ECs via PMPs, and may modulate the expression of target molecule- BCL2L1, which may subsequently display a negative function by modulating EC apoptosis in hypertension. PMID: 28478796
    3. PGAM5 controls cardiomyocyte apoptosis induced by MIRI through regulating Keap1-mediated Bcl-xL degradation, which may supply a novel molecular target for acute myocardial infarction (AMI) therapy. PMID: 27815660
    4. The dependence of the level of expression of Bcl-xL protein on the activity of neurons indicates that this protein possesses one more important property that is essential for participation in neuroplastic processes in the brain. PMID: 28320275
    5. The activation of Bcl-xL expression in the hippocampus by lithium, demonstrated for the first time in this study, suggests an important role of this protein in the therapeutic effects of lithium in the treatment of stress-induced psychoemotional disorders. PMID: 28320276
    6. miR-665 is involved in the neurotoxicity induced by propofol via a caspase-3 mediated mechanism by negatively regulating bcl-2-like protein 1. PMID: 26254736
    7. Bcl-xL regulates neuronal outgrowth during development and protects neurites from hypoxic insult, as opposed by DR6. PMID: 24787232
    8. cyclin B1-Cdk1 complex in the mitochondria phosphorylates the anti-apoptotic protein B-cell lymphoma extra-large PMID: 26109654
    9. data indicate that the BH4 domain of Bcl-XL, but not that of Bcl-2, selectively targets VDAC1 and inhibits apoptosis by decreasing VDAC1-mediated Ca(2+) uptake into the mitochondria PMID: 25681439
    10. The ratio of Bax/Bcl-2 and Bax/Bcl-xL decreased significantly in diabetic animals treated with aminoguanidine. PMID: 24326522
    11. down-regulation of miR-98 in rat uterus during the receptive phase is linked to the increase of cell proliferation via targeting Bcl-xl PMID: 24444606
    12. Data suggest that expression of Bcl-xL in distal colonic mucosa can be up-regulated by dietary fiber (here, by a grape antioxidant dietary fiber preparation). PMID: 22424444
    13. This study suggested that alternative splicing of bcl-x may be an important regulatory mechanism for apoptosis after acute neurological injury, and that splicing regulators may be potential targets for attenuating CNS injury. PMID: 23015448
    14. The data of this study showed that long-term fluoxetine treatment leads to changes in 5-HT and Bcl-xL responses to stress associated with antidepressant-like effects of the drug. PMID: 21740920
    15. ER retention of p75NTR resulted in downregulation of mRNA levels of the anti-apoptotic protein Bcl-xL as well as in strong inhibition of NGF-induced neurite outgrowth in PC12 cells. PMID: 22292018
    16. Bcl-xL is prominently expressed in adult neurons and can be cleaved by caspases to generate a pro-death fragment, DeltaN-Bcl-x(L). PMID: 22366758
    17. In chronic mild stress, downregulated Bcl-xl level is reversed in both hippocampus and myocardium by venlafaxine treatment. PMID: 21308783
    18. Increased mitochondrial energy metabolism efficiency via F1F0 ATPase synthase beta subunit contributes to the enhanced synaptic efficacy found in Bcl-x(L)-expressing neurons. PMID: 21926988
    19. BCL-X1 overexpression reduced the hepatocyte apoptosis and protects mice from fulminant hepatic failure. PMID: 21863631
    20. study shows that GATA-3 plays critical roles in mediating survival signals in osteoblasts, possibly through upregulating bcl-x(L) gene expression PMID: 20499358
    21. The data suggest that naturally occurring variations in the Bcl-xl/Bax ratio in the hippocampus may contribute to individual differences in vulnerability to stress-induced depression-like behaviors PMID: 20457187
    22. Grx1 knockdown in H9c2 cardiomyocytes led to decreased production (mRNA and protein) of anti-apoptotic NFkappaB target gene Bcl-xL & increased baseline & oxidant-induced apoptosis. PMID: 19938943
    23. Bcl-XL has a role in generation of dopamine neurons from neural stem cells PMID: 20106970
    24. Findings suggests that EGb 761 prevents cell death against ischemic brain injury and EGb 761 neuroprotection is affected by preventing the injury-induced increase of Bad and Bcl-X(L) interaction. PMID: 19885947
    25. Spinal cord injury-associated changes in the expression of the antiapoptotic protein Bcl-xL regulates the extent of apoptosis PMID: 11721745
    26. Mitochondrial targeting of Bcl-x(L) requires the COOH-terminal transmembrane (TM) domain flanked at both ends by at least two basic amino acids PMID: 12515824
    27. erythropoietin maintains both genomic DNA integrity and cellular membrane asymmetry through parallel pathways that prevent the induction of Apaf-1 and preserve mitochondrial membrane potential in conjunction with enhanced Bcl-XL expression PMID: 12621307
    28. Bcl-x gene is selectively responsive to oxidative stress, and the response is mediated through distal promoter regions PMID: 12721309
    29. Bcl-X(L) is a key molecule for hypoxia selection of death resistance PMID: 14676192
    30. Bcl-XL overexpression in mature axotomized RGCs in vivo increased both numbers [3.10-fold (+/-0.20)] and cumulative length [6.72-fold (+/-0.47)] of neurites regenerated from retinal explants. PMID: 15121179
    31. Akt1 fosters endothelial cell survival through the prevention of cysteine protease degradation of Bcl-x(L) that is intimately linked to the specific inhibition of caspase 1-, 3-, and 9-like activities PMID: 15149850
    32. Anti-cell death bcl-xL mRNA is attenuated early and tends to remain depressed for at least 3 days after traumatic injury in the cortex and hippocampus ipsilateral to injury. PMID: 15545017
    33. Transfected rat Bcl-X(L) enhances (one-to-two orders of magnitude) the capacity for spontaneous dopaminergic differentiation of human neural stem cells. PMID: 15574729
    34. expression prevented CG-4 (oligodendrocytes) cells from Murine Hepatitis Virus-induced cell death and converted acute to persistent, nonproductive infection. PMID: 15596800
    35. These results suggest that the redox-sensitive transcription factor NF-kappaB may play a role in bcl-X(L)-mediated protection against oxidative cell death. PMID: 15720830
    36. Bcl-xl's protective effects against delayed death may include blocking early damaging events, perhaps by increasing mitochondrial function PMID: 16111822
    37. Ca2+ has a role in regulation of Bcl-xS and Bcl-xL expression and in cell fate PMID: 16301318
    38. Up-regulation of proapoptotic protein Bcl-XS and neuronal apoptosis induced by serum deprivation are blocked by inhibition and/or down-regulation of NF-kappaB and by prevention of K+ loss. PMID: 16428456
    39. the interaction of BAD with membranes is tied to binding of 14-3-3 protein and activation and membrane translocation of Bcl-XL PMID: 16603546
    40. p21-mediated cytoprotection against hyperoxia involves regulation of Bcl-XL and is uncoupled from its ability to inhibit proliferation PMID: 16723699
    41. 1-Bromopropane inhibits nuclear factor kappa B activation to reduce Bcl-xL expression in astrocytes. PMID: 16815550
    42. TMP was found to raise the expression of Bcl-x(L) in rat proximal kidney tubules. PMID: 17132701
    43. Data show that Bcl-x(L) expression is increased in the pulmonary artery undergoing chronic pulmonary vascular remodeling. PMID: 17272823
    44. We showed that dgRb1 could upregulate the expression of not only Bcl-x(L), but also a potent angiogenic and neurotrophic factor, VEGF. PMID: 17600519
    45. Our results suggest that under our experimental conditions, Bcl-x(L) inhibits caspase-dependent apoptosis, but not caspase-independent neuronal death. PMID: 17644076
    46. A high soy diet decreases programmed cell death following tMCAO. Further, a high soy diet enhances expression of the cell survival factor bcl-x(L) following tMCAO, contributing to the neuroprotective effects of soy in the ischemic cortex. PMID: 17706879
    47. the diabetic condition increased the interaction of Bad and Bcl-X(L), and decreased the binding of pBad and 14-3-3. 14-3-3 acts as an anti-apoptotic factor through interaction with Bad PMID: 17870134
    48. Over-expression of the anti apoptotic protein Bcl-xL is responsible for the increased resistance to apoptosis during ischaemic insult PMID: 18053090
    49. Demonstrate segmental heterogeneity in Bcl-xL expression in rat tubular epithelium after ischemia-reperfusion. PMID: 18221257
    50. Bcl-xL positively regulates Drp1 to alter mitochondrial function in a manner that stimulates synapse formatio PMID: 18250306

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  • 亚细胞定位：
    [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Bcl-2 family
  • 组织特异性：
    Expressed in most tissues. Bcl-X(beta) is specifically expressed in cerebellum, heart, and thymus. In the ovary, the predominant form is Bcl-X(L), with a small but detectable level of Bcl-X(S).
  • 数据库链接：

    KEGG: rno:24888

    STRING: 10116.ENSRNOP00000043542

    UniGene: Rn.10323