Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Rat Leukocyte surface antigen CD47 (Cd47)

Recombinant Rat Leukocyte surface antigen CD47 (Cd47)

  • 货号：
    CSB-CF004940RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd47; Leukocyte surface antigen CD47; Integrin-associated protein; IAP; CD antigen CD47
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-303
  • 氨基酸序列
    QLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTRE QNFTSAKISVSDLLKGIASLTMDTHEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTN EKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPG EKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLAVVGMCLCI MACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. Plays an important role in memory formation and synaptic plasticity in the hippocampus.
  • 基因功能参考文献：
    1. down-regulation of CD47 exerts a protective effect against myocardial I/R injury, which may be attributable to attenuation of oxidative stress via activation of the eNOS/nitric oxide signaling pathway. PMID: 27960187
    2. CD47 blockade with CD47mAb400 administered both to the donor and the recipient reduced liver graft ischemia reperfusion injury in a rat liver transplantation model. PMID: 25482981
    3. IAP2 overexpression in neural stem cells induced neuronal differentiation. PMID: 25706387
    4. The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells. PMID: 23799952
    5. These data reveal a novel role for CD47-mediated signaling in the control of the molecular network governing endothelial-dependent T-cell diapedesis. PMID: 23990210
    6. genetic induction of the expression of recipient CD47 on xenogeneic donor cells could provide inhibitory signals to recipient macrophages via SIPRalpha PMID: 23472187
    7. Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1. PMID: 23087362
    8. Data suggest that hyperglycemia induces increase in association of IAP with SHPS-1 (tyrosine phosphatase non-receptor type substrate-1); this appears to be a generalized response of endothelial cells that contributes to endothelial cell dysfunction. PMID: 22193512
    9. IAP plays important roles in dendritic outgrowth and synaptic transmission in developing cortical neurons through the activation of MAPK PMID: 15297459
    10. 4N1K-stimulated mast cell exocytosis involves a CD47/integrin/G(i) protein complex. PMID: 19205621
    11. Amyloid beta peptides trigger CD47-dependent mast cell secretory and phagocytic responses. PMID: 19505377

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 组织特异性：
    Expressed in hippocampus.
  • 数据库链接：

    KEGG: rno:29364

    STRING: 10116.ENSRNOP00000050938

    UniGene: Rn.7409