Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Rat Somatostatin receptor type 2 (Sstr2)

Recombinant Rat Somatostatin receptor type 2 (Sstr2)

  • 货号：
    CSB-CF022725RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Sstr2; Somatostatin receptor type 2; SS-2-R; SS2-R; SS2R; SRIF-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-369
  • 氨基酸序列
    MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCG NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIY AGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGI RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVIL TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTL LNGDLQTSI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
  • 基因功能参考文献：
    1. This study demonstrated that SSTR2 associated with neuronal apoptosis after intracerebral hemorrhage in adult rats. PMID: 29380671
    2. In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy decreased mRNA levels of SSTR2 on day 14 post-infection, although it increased mRNA levels of SSTR2 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model. PMID: 29522573
    3. Chronic mild stress causes significant up-regulation of sst2 receptor in medial habenula PMID: 26462807
    4. All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. SSTR2 was present in all islet endocrine cells except for beta-cells. PMID: 25926390
    5. When the density of sst2A receptors are increased at the plasma membrane in hippocampus there is a decrease in seizure activity. PMID: 26311777
    6. This study demonistrated that sstr2 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain. PMID: 24978951
    7. Filamin A is involved in SST2 stabilization and signaling in tumoral somatotrophs, playing both a structural and functional role. PMID: 24828612
    8. the results described here provide direct evidence in support of cardiac protective role of SSTR2 via modulation of Ca(2+) associated signaling pathways PMID: 24412308
    9. when activated by SST-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 degradation of SST-14 and receptor dissociation from beta-arrestins PMID: 23913690
    10. Our results demonstrate that SST, through the activation of SST2Rs, diminishes presynaptic glutamate release and attenuates status epilepticus PMID: 23473742
    11. Food restriction increased whereas leptin decreased the hippocampal SRIF receptor density, due to changes in SRIF receptor 2 protein levels. PMID: 23073237
    12. Protein phosphatase 1beta (PP1beta) is identified as a phosphatase for the cluster of phosphorylated threonines ((353)TTETQRT(359)) within the sst(2A) somatostatin receptor carboxyl terminus that mediates beta-arrestin binding using siRNA knock-down screening. PMID: 21795688
    13. Decreased level of somatostatin receptor type 2 mRNA and protein in diabetic rat atria leads to the dicrease of atrial natriuretic peptide (ANP) secretion due to an attenuation of suppressive effect of somatostatin on ANP secretion. PMID: 21539874
    14. Selective activation of Sstr2 induces a feeding response in the light phase not associated with changes in gastric emptying. PMID: 20814067
    15. The somatostatin analogs SOM230 and KE108 exhibit functional selectivity at SSTR2, behaving as agonists for some signaling pathways and antagonists for others. Thus they do not mimic the effects of the native peptide at this receptor target. PMID: 19910453
    16. sst(2) receptors mediate inhibition of peristalsis in the jejunum PMID: 11897621
    17. Sst2A receptors are localized to neurons of various morphologies and sizes that occur in clusters throughout most subnuclei of the nucleus tractus solitarii. PMID: 12084407
    18. Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst(2) but not sst(1) receptors are coupled to inhibition of single-cell intracellular free calcium concentrations. PMID: 12169771
    19. regulation of metabolism of this protein by agonists and antagonists PMID: 12403839
    20. SSTR2A receptors are responsible for thermal, but not mechanical, nociceptive transmission in the spinal cord and are preferentially up-regulated. PMID: 12504886
    21. sst2A receptor protein is widely, but selectively, distributed in the hypothalamus, anD postsynaptic sst2A auto- and heteroreceptors are may play an important role in the somatostatinergic regulation of hypothalamic endocrine and metabolic processes. PMID: 12639941
    22. in intracrine-induced cell proliferation SST2 inhibitory signaling may involve the JAK2/SHP-1 pathway. PMID: 12665520
    23. Cocaine administration altered expression of Sstr2 in caudate/putamen. PMID: 12687634
    24. mediates the local inhibitory effect of islet somatostatin on arginine-stimulated glucogon release PMID: 12716749
    25. sst2A receptor-immunoreactive trigeminal nociceptors innervate the nasal mucosa. They may project to the superficial laminae of the medullary dorsal horn. PMID: 12895520
    26. We provide direct evidence for activation of SSTR2 by an endogenous ligand after focal ischemia, which contributes to increased SSTR2 gene expression and postischemic neurodegeneration. PMID: 15601946
    27. Somataostatin action on medial septum/diagonal band of Broca GABAergic neurons, through sst2A receptors, represents an important modulatory mechanism in the control of theta activity. PMID: 15728843
    28. A second pathway is required to induce changes in srif and sst2 expression, since constitutively active calcineurin alone is not sufficient to induce these changes. PMID: 16000155
    29. These results suggest that a SRIF/SHP-1/NO/cGMP mechanism underlies the actions of somatostatin in the retina and in its influence of retinal circuitry. PMID: 16280179
    30. SSTR2 is involved mainly in regulating voltage-gated Ca2+ currents by somatostatin(SRIF), which contributes to the decrease in intracellular Ca2+ concentration and GH secretion by SRIF. PMID: 17327372
    31. Cell division after bilateral adrenalectomy occurs in a specific subpopulation of hormonally null cells that are equally sensitive to the antiproliferative effects of pasireotide and octreotide, implicating SSTR2 receptors in this antimitotic response. PMID: 17347306
    32. somatostatin type 2 receptors traffic in vivo in central neurons from dendrites to the trans Golgi before recycling PMID: 17521381
    33. Somatostatin caused rapid rsst(2a) receptor phosphorylation and desensitization of epithelial antisecretory responses, neither of which occurred with the sst(2b) receptor. PMID: 17603546
    34. Modulation of trigeminal nociceptive transmission in the C(1) dorsal horn by activation of SST(2A) receptors occurs at the level of small-diameter TRG cell bodies and/or their afferent terminals. PMID: 17706880
    35. These studies are the first to show stress-induced changes in amygdala sst2 expression and may represent one mechanism by which psychological stress is linked to adaptive and maladaptive behavioral responses. PMID: 18363859
    36. The inhibition of insulin secretion by somatostatin and somatostatin receptor 2 was attenuated by SNX-482. Taken together, somatostatin and somatostatin receptor 2 regulate [Ca(2+)](i) and insulin secretion in INS-1 cells via R-type channels. PMID: 18793718
    37. neither the glucagon-like peptide-1-induced stimulation of glucagon release nor its inhibition by 20 mmol/l glucose was altered by somatostatin antibody or SSTR2 antagonist administration PMID: 18795252
    38. the subpopulation of bulbospinal rostral ventrolateral medulla neurons that expresses the sst2A receptor sets sympathetic vasomotor output PMID: 19001189
    39. Somatostatin sst2A receptor participates in the development and maturation of specific neuronal populations during rat and human brain ontogenesis. PMID: 19434240

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Cortex, hippocampus, pituitary gland, colon, kidney, and adrenal gland. In the developing nervous system, expressed from E12 when it is restricted to postmitotic neuronal populations leaving the ventricular zone. From E12 on, expressed in migrating neuron
  • 数据库链接：

    KEGG: rno:54305

    STRING: 10116.ENSRNOP00000003735

    UniGene: Rn.202974