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FBL Antibody

  • 货号：
    CSB-PA919400
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extract from 293, Hela cells using Fibrillarin Antibody
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBL Polyclonal antibody
  • Uniprot No.：
    P22087
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around aa.297~301( L-T-L-E-P) derived from Human Fibrillarin
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.
  • 基因功能参考文献：
    1. Fibrillarin acts as a central node in a regulatory network engaged in imparting immunity against bacterial pathogens. PMID: 30190478
    2. Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions. PMID: 27682166
    3. FBL overexpression contributes to tumorigenesis and is associated with poor survival in patients with breast cancer. PMID: 24029231
    4. NS1 protein of the human H3N2 virus interacts primarily via the C-terminal NLS2/NoLS and to a minor extent via the N-terminal NLS1 with the main nucleolar proteins, nucleolin, B23 and fibrillarin. PMID: 22909121
    5. p32 is a new rRNA maturation factor involved in the remodeling from pre-90S particles to pre-40S and pre-60S particles that requires the exchange of FBL for Nop52. PMID: 21536856
    6. Increased levels of exogenous BRAG2 in nucleoli result in redistribution of FBL to the nucleolar periphery. PMID: 17461797
    7. Our data suggest that fibrillarin would play a critical role in the maintenance of nuclear shape and cellular growth. PMID: 17603021
    8. Evidence that BIG1 and nucleolin, but not fibrillarin, can be present with p62 at the nuclear envelope confirms the presence of BIG1 and nucleolin in dynamic molecular complexes that change in composition while moving through nuclei PMID: 18292223
    9. Data demonstrate that fibrillarin and Nop56 directly interact in vivo, and that this interaction is indispensable for the association of both proteins with the box C/D snoRNPs. PMID: 19331828

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  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Fibrillar region of the nucleolus.
  • 蛋白家族：
    Methyltransferase superfamily, Fibrillarin family
  • 数据库链接：

    HGNC: 3599

    OMIM: 134795

    KEGG: hsa:2091

    STRING: 9606.ENSP00000221801

    UniGene: Hs.299002