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RAB23 Antibody

  • 货号：
    CSB-PA891960ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RAB23 antibody at 3.88μg/ml
      Lane 1: Mouse ocular tissue
      Lane 2: Rat brain tissue
      Lane 3: Mouse kidney tissue
      Lane 4: Mouse lung tissue
      Lane 5: Mouse brain tissue
      Lane 6: NIH/3T3 whole cell lysate
      Lane 7: MCF-7 whole cell lysate
      Lane 8: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 27 kDa
      Observed band size: 27 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA891960ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA891960ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    CUSABIO's product CSB-PA891960ESR1HU is a polyclonal antibody raised in the rabbit against a peptide mapping within amino acids 1-237 of the human RAB23 protein. This RAB23 antibody occurs as an unconjugated IgG. Purification by antigen affinity method reaches a relatively high purity. It is reactive to human, mouse, and rat samples. And it has been demonstrated to recognize RAB23 protein in the ELISA, WB, and IHC applications. Its target protein RAB23 is a small GTPase that exerts important development functions in vertebrates and regulates Sonic hedgehog (Shh) and Nodal signaling.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAB23 Polyclonal antibody
  • Uniprot No.：
    Q9ULC3
  • 基因名：
    RAB23
  • 别名：
    DKFZp781H0695 antibody; HSPC137 antibody; MGC8900 antibody; Rab 23 antibody; RAB family small GTP binding protein RAB 23 antibody; Rab23 antibody; RAB23; member RAS oncogene family antibody; RAB23_HUMAN antibody; Ras related protein Rab 23 antibody; Ras-related protein Rab-23 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Ras-related protein Rab-23 protein (1-237AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.
  • 基因功能参考文献：
    1. Genetic variants in RAB23 and ANXA11 genes were associated with an increased risk of sarcoidosis-associated uveitis. PMID: 29416296
    2. miR-429 was down-regulated in hepatocellular carcinoma (HCC) tissues and cells. Up regulation of miR-429 decreased the migratory capacity and reversed the EMT to MET in HCC cells. RAB23 was confirmed as a target of miR-429. PMID: 29191386
    3. Down-regulation of Rab23 suppressed the proliferation, migration and invasion of prostate cancer cells. PMID: 28277196
    4. Rab23 serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through Rac1 activity PMID: 26897750
    5. High Rab23 expression is associated with bladder cancer. PMID: 26715272
    6. Forced expression of MiR-92b decreased the mRNA and protein level of RAB23, and RAB23 rescued the biological functions of miR-92b. Taken together, this study revealed the oncogenic roles and the regulation of RAB23 in esophageal squamous cell carcinoma, suggesting RAB23 might be a therapeutic target PMID: 27659550
    7. Rab23 enhance squamous cell carcinoma cell invasion via up-regulating Rac1. PMID: 26648292
    8. Rab23 is expressed in breast cancer cells, and ectopic expression of Rab23 inhibits the growth and proliferation as well as induces cell apoptosis in breast cancer cells These effects may be due to the inhibition by Rab23 of Gli1 and Gli2 mRNA expression PMID: 26238143
    9. Data indicate the essential role of GTP binding protein RAB 23 (Rab23) in pancreatic ductal adenocarcinoma (PDAC) inva-sion, motility and metastasis. PMID: 25867419
    10. Rab23 was a target gene of miR-367, and ectopic expression of Rab23 could reverse the invasion and migration inhibitory activity of miR-367. PMID: 25489984
    11. The inhibition of the Rab23 cycle decreases the expression and nuclear localization of Gli1. PMID: 23007279
    12. Rab23 expression level was the highest in Bcap-37 cells. PMID: 23948406
    13. Rab9A and Rab23 GTPases play crucial roles in autophagy of Group A Streptococcus. PMID: 22452336
    14. association of the 6p12.1 locus with sarcoidosis implicates this locus as a further susceptibility factor and RAB23 as a potential signalling component PMID: 21540310
    15. Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay PMID: 21412941
    16. A RAB23 mutation (c.86dupA) present in the homozygote state in four relatives of Comorian origin with Carpenter syndrome, is reported. PMID: 20358613
    17. Rab23 is overexpressed and/or activated in hepatocellular carcinoma (HCC). Rab23 may be both a HCC predictor and a target for treating HCC. PMID: 17373734
    18. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development. PMID: 17503333
    19. Data show that RAB23 participates in central nervous system development. PMID: 18485483
    20. RAB23 amplifications are associated with gastric cancer PMID: 18559507

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  • 相关疾病：
    Carpenter syndrome 1 (CRPT1)
  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 数据库链接：

    HGNC: 14263

    OMIM: 201000

    KEGG: hsa:51715

    STRING: 9606.ENSP00000320413

    UniGene: Hs.555016