Recombinant Human Tapasin (TAPBP)

1. The results demonstrated that the mRNA expression levels of tapasin were significantly downregulated in patients with chronic hepatitis B (CHB) compared with in healthy controls and patients with acute hepatitis B Furthermore, the apoptotic rate of CD8+ T cells was increased in patients with CHB compared with in the other two groups. PMID: 27510296
2. Fluctuation and entropy analyses show how tapasin chaperones major histocompatibility complex class I by stabilising it in a peptide-receptive conformation. PMID: 26754481
3. reduction in tapasin expression is associated with tumor progression in colorectal cancer PMID: 26310568
4. Data suggest that tapasin (Tsn) binds to MHC I with suboptimal cargo and thereby adjusts the energy landscape in favor of MHC I complexes with immunodominant epitopes. PMID: 26416272
5. Analysis of expression of tapasin and/or HLA-I may be of value as prognostic tool for glioblastoma multiforme patients, especially when considering immunotherapy. PMID: 25175688
6. Modified TAPBP gene function may contribute to the development of refractory chronic rhinosinusitis via reduction of circulating CD8 lymphocytes. PMID: 23640800
7. Targeted re-sequencing identified rs3106189 at the 5' UTR of TAPBP and rs1052918 at the 3' UTR of TCF3 to be associated with the overall survival of colorectal cancer patients. PMID: 23940558
8. the data indicate that TAPBPR and tapasin bind in a similar orientation to the same face of MHC class I. PMID: 24163410
9. TAPBP polymorphisms may play a role in the development of aspirin-exacerbated respiratory disease. PMID: 23736108
10. isoform lacking exon 3 affects MHC class I-peptide binding PMID: 23519916
11. Data indicate that the peptide-loading complex (PLC) consists maximally of 2x tapasin-ERp57/MHC I per TAP complex, but one tapasin-ERp57/MHC I in the PLC is essential and sufficient for antigen processing. PMID: 22923333
12. Tapasin discriminates peptide-human leukocyte antigen-A*02:01 complexes formed with natural ligands. PMID: 21518758
13. On infection with human cytomegalovirus tapasin mRNA levels were continuously downregulated during infection, while tapasin transcripts remained stable and long-lived. PMID: 21248040
14. Downregulation of tapasin is associated with a poor clinical outcome for oral squamous cell carcinoma patients and may serve as a prognostic biomarker PMID: 20532727
15. The interactions of tapasin with both TAP and ERp57 are correlated with strong MHC class I recruitment and assembly enhancement. PMID: 20070606
16. find that in a competitive situation between high- and low-affinity peptides, tapasin mediates the binding of the high-affinity peptide to class I by accelerating the dissociation of the peptide from an unstable intermediate of the binding reaction. PMID: 20017190
17. recruits MHC class I molecules to TAP complex during antigen processing PMID: 11823531
18. tapasin is a modified Mhc class I molecule PMID: 11862402
19. MHC class I molecules can optimize their peptide repertoire over time and that this process is dependent on tapasin. PMID: 11970875
20. tapasin is not required for calreticulin to bind to the alpha1 domain of MHC class I molecules PMID: 11972874
21. results suggest that tapasin deficiency is another cause of type I bare lymphocyte syndrome PMID: 12149238
22. Tapasin enhances the structural stability of TAP1.TAP2 complexes. PMID: 12213826
23. The domain organization of tapasin is an assembly of two core regions of different sizes loosely connected by a linker or loop comprising residues ~85-93. PMID: 12463753
24. tapasin has a essential function of tapasin in quality control of HLA-G molecules PMID: 12582157
25. A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. PMID: 12594855
26. Downregulation of tapasin in advanced stages of human melanoma may reflect accumulation of alterations in antigen-presenting/processing machinery associated with neoplastic progression. May contribute to immune escape phenotype of human melanoma cells. PMID: 12682852
27. The ERp57-tapasin conjugate can also be modified with the oxidizing agent diamide, indicating that within the pool of ERp57-tapasin complexes the free, non-tapasin-linked CXXC motif exists in both oxidized and reduced states PMID: 13678524
28. Defects in tapasin and HLA class I antigen expression in primary maxillary sinus SCC lesions may play a role in the clinical course of the maxillary sinus cancer, because these defects were associated with poor prognosis. PMID: 14519625
29. In its role as peptide facilitator, tapasin stabilizes the peptide-free conformation of class I major histocompatibility (MHC) complex molecules in the endoplasmic reticulum and thus increases the number and variety of peptides bound to class I MHC. PMID: 14607930
30. Mutational analysis of tapasin provides insight into aspects of tapasin structure that are crucial to its ability to assist major histocompatibility complex class I assembly. PMID: 14978101
31. Transfection of tapasin into the Panc02 cells did not quantitatively increase MHC class I surface expression or detectably affect MHC class I association with tumor-specific peptides and beta(2)-microglubulin (beta(2)m). PMID: 15163903
32. Defective tapasin transcription and thus absence of HLA-B44 expression is associateed with colorectal tumors. PMID: 15455354
33. Substitutions at position lysine-408 in tapasin are shown to affect the expression of major histocompatibility complex class I molecules at the cell surface, by down-regulating tapasin stabilization of TAP. PMID: 15634919
34. Tapasin association specifically inhibits the escape pathway required for disulfide-bond isomerization within conventional protein substrates, suggesting a specific structural role for ERp57 within the MHC class I peptide-loading complex. PMID: 16193070
35. Down-regulation of tapasin expression was associated with glioblastoma multiforme PMID: 16322289
36. Besides beta(2)m and tapasin, an extra unidentified component is also critical for the expression of certain human class I alleles. PMID: 17498802
37. A ternary complex between heavy chain, ERp57, and tapasin was observed and shown to be stabilized by a disulfide between both tapasinheavy chain and tapasin-ERp57. PMID: 18039656
38. Transgenic tapasin establishes hierarchical responses in vivo according to peptide-major histocompatibility complex class I stability. PMID: 18196518
39. In this review, interaction of accessory protein tapasin with HLA-DM crucially influences the selection of peptides that bind to major histocompatibility complex (MHC) molecules during antigen presentation. PMID: 18261958
40. the 2.6 A resolution structure of the tapasin-ERp57 core of the peptide-loading complex PMID: 19119025
41. HLA-B27 polymorphism drives the tapasin dependency, rates of intracellular maturation and expressions of homodimers. PMID: 19167761
42. tapasin conjugation with ERp57 is as critical as its integration into the membrane for efficient MHC class I assembly, surface expression, and Ag presentation to CD8+ T cells. PMID: 19701894
43. The N-terminal region of Tapasin (Tpn) can be recombinantly expressed and adopt a structure, which at least partially resembles that of wild-type Tpn. This region of Tpn features chaperone activity facilitating peptide binding of MHC-I. PMID: 19728311

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HGNC: 11566

OMIM: 601962

KEGG: hsa:6892

STRING: 9606.ENSP00000404833

UniGene: Hs.370937