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CCR5

CCR5(趋化因子受体5)是一种G蛋白偶联受体,由352个氨基酸残基组成,分子量约为40.6kDa。其结构包括胞外N末端、三个胞外环(EL1、EL2、EL3)、三个胞内环(IL1、IL2、IL3)、7个跨膜α螺旋和胞内C末端。CCR5主要在免疫细胞上表达,如记忆性的静止期T淋巴细胞、单核细胞、未成熟的树突状细胞等,调控这些细胞的迁移、增殖与免疫反应。CCR5的功能涉及免疫细胞迁移调控、免疫应答以及作为HIV-1早期侵染的辅助受体,参与病毒与宿主细胞的结合和膜融合过程。 CCR5参与的信号通路主要包括趋化因子信号通路,与趋化因子结合后激活G蛋白信号转导,进而激活下游的细胞内信号级联,促进免疫细胞的活化和增殖。此外,CCR5的N末端和第二胞外区与HIV-1的gp120糖蛋白相互作用,协助病毒进入宿主细胞。某些CCR5的突变体,例如CCR5Δ32,能够抵抗HIV的感染并延缓病情恶化。这些发现表明CCR5在免疫应答和HIV-1感染中发挥着重要作用,是研究和治疗相关疾病的潜在靶点。

CCR5 Antibodies

CCR5 for Homo sapiens (Human)

CCR5 for Mus musculus (Mouse)

CCR5 Proteins

CCR5 Proteins for Mus musculus (Mouse)

CCR5 Proteins for Macaca mulatta (Rhesus macaque)

CCR5 Proteins for Papio anubis (Olive baboon)

CCR5 Proteins for Papio hamadryas (Hamadryas baboon)

CCR5 Proteins for Homo sapiens (Human)

CCR5 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

CCR5 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

CCR5 Proteins for Pan troglodytes (Chimpanzee)

CCR5 Proteins for Semnopithecus entellus (Hanuman langur) (Presbytis entellus)

CCR5 Proteins for Macaca nemestrina (Pig-tailed macaque)

CCR5 Proteins for Pongo abelii (Sumatran orangutan)

CCR5 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

CCR5 Proteins for Lophocebus aterrimus (Black crested mangabey) (Cercocebus aterrimus)

CCR5 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CCR5 Proteins for Rattus norvegicus (Rat)

CCR5 Proteins for Trachypithecus francoisi (Francois's leaf monkey) (Presbytis francoisi)

CCR5 Proteins for Pygathrix nemaeus (Dove langur) (Douc langur)

CCR5 Proteins for Trachypithecus phayrei (Phayre's leaf monkey)

CCR5 Proteins for Pongo pygmaeus (Bornean orangutan)

CCR5 Proteins for Macaca arctoides (Stump-tailed macaque)

CCR5 Proteins for Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)

CCR5 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

CCR5 Proteins for Pygathrix bieti (Black snub-nosed monkey) (Rhinopithecus bieti)

CCR5 Proteins for Rhinopithecus avunculus (Tonkin snub-nosed monkey) (Pygathrix avunculus)

CCR5 Proteins for Oryctolagus cuniculus (Rabbit)

CCR5 Proteins for Bos taurus (Bovine)

CCR5 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CCR5 Proteins for Callithrix humeralifera (Tassel-eared marmoset)

CCR5 Proteins for Saimiri sciureus (Common squirrel monkey)

CCR5 Proteins for Hylobates syndactylus (Siamang) (Symphalangus syndactylus)

CCR5 Proteins for Theropithecus gelada (Gelada baboon)

CCR5 Proteins for Alouatta seniculus (Red howler monkey)

CCR5 Proteins for Ateles geoffroyi (Black-handed spider monkey)

CCR5 Proteins for Mandrillus sphinx (Mandrill) (Papio sphinx)

CCR5 Proteins for Hylobates moloch (Silvery gibbon)

CCR5 Proteins for Colobus polykomos (Western black-and-white colobus monkey)

CCR5 Proteins for Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin)

CCR5 Proteins for Mandrillus leucophaeus (Drill) (Papio leucophaeus)

CCR5 Proteins for Trachypithecus johnii (Nilgiri langur) (Semnopithecus johnii)

CCR5 Proteins for Nasalis larvatus (Proboscis monkey)

CCR5 Proteins for Callicebus moloch (Dusky titi monkey)

CCR5 Proteins for Erythrocebus patas (Red guenon) (Cercopithecus patas)

CCR5 Proteins for Cercopithecus tantalus (Tantalus monkey) (Chlorocebus tantalus)

CCR5 Proteins for Cercopithecus solatus (Sun-tailed monkey)

CCR5 Proteins for Cercopithecus ascanius (Black-cheeked white-nosed monkey) (Redtail monkey)

CCR5 Proteins for Cercocebus galeritus (Tana river mangabey)

CCR5 Proteins for Cercopithecus cephus (Moustached monkey)

CCR5 Proteins for Cercopithecus nictitans (Greater white-nosed monkey) (White-nosed guenon)

CCR5 Proteins for Cercopithecus pygerythrus (Vervet monkey)

CCR5 Proteins for Cercopithecus sabaeus (Green monkey) (Chlorocebus sabaeus)

CCR5 Proteins for Cercopithecus lhoesti (L'Hoest's monkey)