CCR8
CCR8：Tregs细胞的特异性靶点，催生下一代重磅肿瘤免疫药物！
CCR8在肿瘤浸润的调节性T细胞（Treg）上特异性表达，在辅助型T细胞2（Th2）和肿瘤细胞也均有表达；然而在外周血Treg或正常组织上基本不表达。CCR8的主要作用是参与Tregs和Th2细胞向炎症和肿瘤部位的募集。Tregs增强了肿瘤细胞的浸润能力，通过抑制攻击肿瘤的免疫细胞的免疫反应，从而使肿瘤细胞发生免疫逃逸。研究发现，与正常组织中的Tregs相比，CCR8在人类乳腺癌的肿瘤浸润性Tregs中显著上调，表明CCR8是TME中Tregs上的一个有希望的治疗靶点，而不会引起系统性自身免疫。因此，以CCR8为靶点的抗体，清除肿瘤微环境中的Treg细胞，将改善TME的免疫功能。
CUSABIO-哺乳包膜VLPs平台成功开发CCR8全长膜蛋白（7次跨膜），展示了完整生物活性。
Recombinant Human CCR8-VLPs 活性蛋白实验验证数据
● 经WB验证蛋白特异性
CSB-MP004847HU is detected by Mouse anti-6*His monoclonal antibody.
CSB-MP004847HU is detected by Anti-CCR8 recombinant Antibody
● 功能性ELISA验证高活性
Immobilized human CCR8 at 5 μg/ml can bind Anti-CCR8 recombinant Antibody. The EC50 is 11.13-17.29 ng/mL.
● 经TEM验证蛋白正确组装
The VLP-like structures of CCR8 has been confirmed by TEM.
CCR8 Antibodies
CCR8 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA091770 | CCR8 Antibody | Human | ELISA,WB,IHC |
| CSB-PA172806 | CCR8 Antibody | Human | ELISA,WB,IHC |
| CSB-RA004847A1HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
| CSB-RA004847MA2HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
| CSB-RA004847MA3HU | CCR8 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CCR8 Proteins
CCR8 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-EP004847HU1 CSB-BP004847HU1 CSB-MP004847HU1 CSB-EP004847HU1-B |
Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004847HU | Recombinant Human C-C chemokine receptor type 8 (CCR8) | in vitro E.coli expression system |
| CSB-CF004847HU2 | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | in vitro E.coli expression system |
| CSB-CF004847HU2-N | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial,Nanodiscs | in vitro E.coli expression system |
| CSB-YP004847HU1 | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | Yeast |
| CSB-MP004847HU | Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active) | Mammalian cell |
CCR8 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004847MO1 CSB-EP004847MO1 CSB-BP004847MO1 CSB-MP004847MO1 CSB-EP004847MO1-B |
Recombinant Mouse C-C chemokine receptor type 8 (Ccr8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004847MO | Recombinant Mouse C-C chemokine receptor type 8 (Ccr8) | in vitro E.coli expression system |
| CSB-MP004847MO | Recombinant Mouse C-C chemokine receptor type 8 (Ccr8)-VLPs | Mammalian cell |
CCR8 Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004847MOW1 CSB-EP004847MOW1 CSB-BP004847MOW1 CSB-MP004847MOW1 CSB-EP004847MOW1-B |
Recombinant Macaca mulatta C-C chemokine receptor type 8 (CCR8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004847MOW | Recombinant Macaca mulatta C-C chemokine receptor type 8 (CCR8) | in vitro E.coli expression system |
