CSF2RB
粒细胞-巨噬细胞集落刺激因子低亲和力受体β(Colony Stimulating Factor 2 Receptor,Beta,Low-Affinity,CSF2RB),又叫CD131,是一种多重集落刺激因子受体。CSF2RB对JAK/STAT(JAK2,STAT5)和MAP激酶途径的激活都至关重要。人IL-3、GM-CSF、IL-5通过细胞膜表面相应的受体发挥相应的生物学功能。这三种细胞因子受体由各自特异性的a亚基(IL-3Ra、GM-CSFRa、IL-5Ra)和共有的β亚基组成,三种a亚基竞争性结合β亚基,形成高亲和力受体。a亚基特异性结合相应的细胞因子,共同亚基(hβc),即CD131,起传导信号作用。通常将这三种细胞因子的受体称IL-3受体系统,在维持造血细胞增殖、分化、自我更新的平衡中具有重要作用。有研究人员利用转基因小鼠发现CSF2RB基因的突变在骨髓增生性疾病中起作用,且转基因的小鼠出现了散发性的神经系统疾病。因此,CSF2RB的激活可能与中枢神经系统疾病有关。另有研究揭示CSF2RB相关信号通路的活化与脊髓损伤有关。
Recombinant Human CSF2RB 活性蛋白实验验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CSF2RB at 2 μg/ml can bind anti-CSF2RB antibody(CSB-RA006047A0HU), the EC50 is 0.1594-0.3046 ng/mL.
CSF2RB Antibodies
CSF2RB for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA003029 | CSF2RB Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA007339 | Phospho-CSF2RB (Y593) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA200894 | CSF2RB Antibody | Human | ELISA,IHC |
CSB-PA598159 | CSF2RB Antibody | Human | ELISA,IHC |
CSB-PA006047LA01HU | CSF2RB Antibody | Human | ELISA, IHC, IF |
CSB-RA006047A0HU | CSF2RB Recombinant Monoclonal Antibody | Human | ELISA |
CSF2RB Proteins
CSF2RB Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP006047MO CSB-EP006047MO CSB-BP006047MO CSB-MP006047MO CSB-EP006047MO-B |
Recombinant Mouse Cytokine receptor common subunit beta (Csf2rb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2RB Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP006047HU CSB-EP006047HU CSB-BP006047HU CSB-EP006047HU-B |
Recombinant Human Cytokine receptor common subunit beta (CSF2RB), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP006047HU | Recombinant Human Cytokine receptor common subunit beta (CSF2RB), partial (Active) | Mammalian cell |